Thiamethoxam Exposure Impairs Oocyte Maturation via Induction of Lipid Metabolism and Mitochondrial Dysfunctions in Porcine.

Neonicotinoid insecticides (NEOs) are the most widely used pesticides in modern agriculture, and there are residues in the environment and food. Thiamethoxam (TMX) has been proven to destroy the ovarian homeostasis of mice in vivo and reduce the development of porcine oocytes in vitro. However, whether TMX can interfere with porcine oocyte maturation and its potential mechanism remains unknown.

[Newest Advances in Diagnosis and Treatment of Plasmablastic Lymphoma --Review].

Plasmablastic lymphoma (PL/PBL) is a rare type of lymphoma with strong aggressive ability and poor prognosis. Currently,there is a lack of strict diagnostic and therapeutic criteria. In addition to traditional plasma cell markers, SLAMF7 may be a useful adjunct to diagnostic markers for PBL.

Successful treatment of solitary bladder plasmacytoma: A case report.

Background: Plasmacytoma is a rare neoplastic disorder that arises from B-lymphocytes. Solitary bladder plasmacytoma, a type of solitary extramedullary plasmacytoma, is even rarer. Treatments for solitary extramedullary plasmacytoma include surgery, chemotherapy, and radiation.

RMBase v2.0: deciphering the map of RNA modifications from epitranscriptome sequencing data.

More than 100 distinct chemical modifications to RNA have been characterized so far. However, the prevalence, mechanisms and functions of various RNA modifications remain largely unknown. To provide transcriptome-wide landscapes of RNA modifications, we developed the RMBase v2.

[Effects of paeoniflorin on expressions of CTGF, PDGF and TNF-alpha in mice with hepatic fibrosis due to Schistosoma japonicum infection].

Objective: To observe the effects of paeoniflorin on the expressions of CTGF and PDGF in liver tissue of fibrosis and the serum level of TNF-alpha in mice infected with Schistosoma japonicum, and to explore the protective effect and its mechanisms of paeoniflorin on liver fibrosis.

Methods: Kunming mice were divided randomly into 5 groups, namely normal control group (Group A), paeoniflorin groups (Group B, C, D) and infected control group (Group E). The mice in Group B-E were infected with cercariae of Schistosoma japonicum, and then they were treated with praziquantel (400 mg/kg per day) for 2 days after 6 weeks.