Upfront Colectomy vs. Initial Appendectomy followed by Completion Colectomy for Appendiceal Cancer: A Comparison of Outcomes.

Objective: Determine whether staged right colectomy for appendiceal cancer (initial appendectomy followed by completion colectomy - SRC) is detrimental to oncologic outcomes compared to upfront right colectomy (URC).

Background: The decision to perform right hemicolectomy for appendiceal cancer depends on histologic features of the primary tumor. SRC allows for histologic assessment of primary tumor and may avoid an unnecessary right colectomy if not indicated.

Risk of Open Conversion During Robotic Gastrectomy for Gastric Cancer: Optimizing Patient Selection.

Background And Objectives: Robotic surgery for gastric adenocarcinoma (GC) shows recovery benefits compared to open and laparoscopic approaches. While open conversion (OC) is associated with poorer outcomes, factors influencing robotic gastrectomy (RG) OC are obscure. We identified preoperative and intraoperative risk factors for OC and associated outcomes.

Metabolic Profile of Senegalese Sole () Muscle: Effect of Fish-Macroalgae IMTA-RAS Aquaculture.

The aquaculture sector is essential for meeting seafood demand while ensuring sustainability. It involves farming fish, mollusks, crustaceans, other invertebrates, and algae in controlled environments, helping to conserve marine resources and reduce ecological pressures. Sustainable practices, such as an integrated multitrophic recirculating aquaculture system (IMTA-RAS) with fish and seaweed, can minimize the environmental impact of fish aquaculture.

Comparison of Cancer Care Delivery and Outcomes in Medicare Advantage with Traditional Medicare.

Objective: Determine the effect of Medicare insurance status on quality of care and survival in cancer patients.

Background: Nearly half of current Medicare beneficiaries now enroll in Medicare Advantage (MA) plans and there is limited understanding of how overall cancer care and outcomes vary in MA compared to Traditional Medicare (TM).

Methods: Medicare beneficiaries undergoing treatment for stage 1-4 lung, esophageal, gastric, pancreatic, colon, and rectal cancer from 2000-2019 in California were identified.

Combining xQTL and genome-wide association studies from ethnically diverse populations improves druggable gene discovery.

Repurposing existing medicines to target disease-associated genes represents a promising strategy for developing new treatments for complex diseases. However, progress has been hindered by a lack of viable candidate drug targets identified through genome-wide association studies (GWAS). Gene-based association tests provide a more powerful alternative to traditional single nucleotide polymorphism (SNP)-based methods, yet current approaches often fail to leverage shared heritability across populations and to effectively integrate functional genomic data.

Bioactive withanolides from the leaves of Athenaea velutina (Sendtn.) D'Arcy.

Withanolides are a substantial bio-diverse group of naturally occurring steroidal lactones. Herein, ten still undescribed withanolides (1-10), along with the knowns withaferin A (11), 2,3-dihidrowithaferin A (12), and two other non-withanolides, vomifoliol (13) and the N-trans-p-coumaroyltyramine (14), were isolated from the hexane/EtOAc 1:1 leaf extract of Athenaea velutina (Sendtn.) D'Arcy (Solanaceae).

Lipid nanoformulations as a platform for antihypertensive applications of a ruthenium nitrosyl compound.

Nitric oxide (NO) and derivatives play key roles in immunomodulation and blood pressure regulation. Nitrosyl ruthenium complexes are studied as vasorelaxant agents with potential applications in cardiovascular and parasitic diseases. Lipid nanoemulsions enhance their stability and bioavailability.

Impact of Overnight Fasted State Versus Fed State on Adaptations to Resistance Training: A Randomized Clinical Trial.

The aim was to verify the effects of 12 weeks of resistance training (RT) performed in the fasted state compared with the fed state on body composition and physical performance in young adults. Participants were randomly assigned into fasting RT group (Fast-RT, n = 15) and fed RT group (Fed-RT, n = 13). Both groups trained two weekly resistance exercise sessions after an overnight fast or between 1 and 2 hr after consumption of a carbohydrate-rich meal, associated with isocaloric nutritional guidance.

What changed after two years of COVID-19: the PAMPA Cohort update profile and methodology.

The PAMPA Cohort aimed to evaluate the long-term impact of the COVID-19 pandemic on the physical and mental health outcomes of adults. We present data from the fourth wave of the PAMPA Cohort, the updated cohort profile and methodology. The PAMPA Cohort is a prospective study initially designed to have three data collection waves (June 2020, December 2020, and June 2021).

Randomized Controlled Trial - Perioperative Telemonitoring of Patient Generated Health Data in Gastrointestinal Oncologic (GI) Surgery: Assessing Outcomes.

Objective: To determine whether perioperative monitoring with nursing triage intervention is feasible and improves surgical outcomes and recovery.

Background: There are increased demands for outpatient recovery after complex gastrointestinal oncologic surgery with simultaneous expectations of improving quality of life and expedited functional recovery. Telemonitoring is a proposed mechanism to achieve these goals.

Feasibility of Robotic Surgical Approach in Peritoneal Carcinomatosis.

Introduction: Advances in robotic instrumentation have facilitated minimally invasive completion of complex cancer operations. The objective of this study is to determine the feasibility of robotic approach for cytoreduction (R-CRS) for peritoneal carcinomatosis in a series of 16 consecutive cases.

Methods: Single institution retrospective study of consecutive patients with peritoneal carcinomatosis deemed appropriate for R-CRS after multidisciplinary review between 2017 and 2022.

Access pathways to the transsexualizing process in Brazil: a scoping review.

Objective: To analyze the representation of access pathways to the transsexualizing process in Brazil and the main barriers faced by transgender people.

Method: A scoping review of the literature was conducted. Searches took place in January 2024, with articles and reviews that addressed access to the transsexualizing process being eligible, while books, chapters, conferences, editorial documents, and studies describing surgical procedures were excluded.

Pharmacological evaluation of a new nanoformulation in the erectile tissue of rabbits and humans.

The failure of achieving a penile erection for satisfactory sexual intercourse is known as erectile dysfunction (ED). The primary mediator for penile erection is nitric oxide (NO). ED is often associated with endothelial/nitrergic dysfunction characterized by a reduction of the bioavailability of NO.

Symbolic information approach applied to human intracranial data to characterize and distinguish different congnitive processes.

How the human brain processes information during different cognitive tasks is one of the greatest questions in contemporary neuroscience. Understanding the statistical properties of brain signals during specific activities is one promising way to address this question. Here we analyze freely available data from implanted electrocorticography (ECoG) in five human subjects during two different cognitive tasks in the light of information theory quantifiers ideas.

Chemokine receptors in COVID-19 infection.

Chemokine receptors play diverse roles in the immune response against pathogens by recruiting innate and adaptive immune cells to sites of infection. However, their involvement could also be detrimental, causing tissue damage and exacerbating respiratory diseases by triggering histological alterations such as fibrosis and remodeling. This chapter reviews the role of chemokine receptors in the immune defense against SARS-CoV-2 infection.

Association of negative pressure wound therapy and surgical site infections in patients undergoing cytoreductive surgery: An entropy balanced analysis.

Background And Objectives: Surgical site infections (SSIs) after cytoreductive surgery (CRS) ± hyperthermic intraperitoneal chemotherapy (HIPEC) are a major cause of potentially avoidable morbidity. We explored the association of negative pressure wound therapy (NPWT) with SSI in patients undergoing CRS/HIPEC.

Methods: Retrospective analysis of consecutive patients undergoing CRS/HIPEC for non-gynecologic cancers.

Association between food insecurity and long COVID in adults from southern Brazil: findings of the PAMPA cohort.

Background: Social and economic factors, such as food insecurity, contribute to long coronavirus disease (COVID). During the pandemic, a significant rise in food insecurity was observed, both in Brazil and worldwide. We aimed to investigate the association between food insecurity and long COVID in Brazilian adults.

Anti-bacterial, anti-biofilm and synergistic effects of phenazine-based ruthenium(II) complexes.

Antimicrobial resistance has become a global threat to human health, which is coupled with the lack of novel drugs. Metallocompounds have emerged as promising diverse scaffolds for the development of new antibiotics. Herein, we prepared some metal compounds mainly focusing on -[Ru(bpy)(dppz)(SO)(NO)](PF) (PR02, bpy = 2,2'-bipyridine, dppz = dipyrido[3,2-:2',3'-]phenazine), in which phenazinic and nitric oxide ligands along with sulfite conferred some key properties.

Who should get a right colectomy in low-grade appendiceal adenocarcinomas? Association of lymphovascular invasion and nodal metastases.

Background: There is variation in the probability of nodal metastases from low-grade appendiceal adenocarcinomas, and the role of right colectomy is unclear. We aimed to define the prevalence and utility of lymphovascular invasion in predicting the risk of nodal metastases to help stratify patients who may benefit from right hemicolectomy.

Methods: Patients with nonmetastatic low-grade appendiceal adenocarcinomas were identified from the National Cancer Database (2010-2017).

Diffuse-Type Histology Is Prognostic for All Siewert Types of Gastroesophageal Adenocarcinoma.

Purpose: The optimal treatment for gastroesophageal junction adenocarcinoma (GEJA) remains controversial. We evaluated the treatment patterns and outcomes of patients with locally advanced GEJA according to the histological type.

Materials And Methods: We conducted a single-institution retrospective cohort study of patients with locally advanced GEJA who underwent curative-intent surgical resection between 2010 and 2020.

Strain tracking in complex microbiomes using synteny analysis reveals per-species modes of evolution.

Microbial species diversify into strains through single-nucleotide mutations and structural changes, such as recombination, insertions and deletions. Most strain-comparison methods quantify differences in single-nucleotide polymorphisms (SNPs) and are insensitive to structural changes. However, recombination is an important driver of phenotypic diversification in many species, including human pathogens.

Gouy phase and quantum interference with cross-Wigner functions for matter-waves.

The Gouy phase is essential for accurately describing various wave phenomena, ranging from classical electromagnetic waves to matter waves and quantum optics. In this work, we employ phase-space methods based on the cross-Wigner transformation to analyze spatial and temporal interference in the evolution of matter waves characterized initially by a correlated Gaussian wave packet. First, we consider the cross-Wigner of the initial wave function with its free evolution, and second for the evolution through a double-slit arrangement.