Climate change and child health: The growing burden of climate-related adverse health outcomes.

Climate change is increasingly recognized not only as an environmental issue but also as a major public health threat, becoming more evident through the rising frequency and intensity of extreme weather events. Immediate exposure to climate-related hazards-such as extreme heat, wildfires, storms, and floods-results in direct health impacts, while indirect effects emerge through ecosystem disruptions and socioeconomic shifts. Climate change can introduce or intensify health risks in regions that were previously unaffected.

MicroRNA Screening Reveals Upregulation of FoxO-Signaling in Relapsed Acute Myeloid Leukemia Patients.

: AML is an aggressive malignant disease characterized by aberrant proliferation and accumulation of immature blast cells in the patient's bone marrow. Chemotherapeutic treatment can effectively induce remission and re-establish functional hematopoiesis. However, many patients experience chemoresistance-associated relapse and disease progression with a poor prognosis.

MicroRNA Expression Patterns Reveal a Role of the TGF-β Family Signaling in AML Chemo-Resistance.

Resistance to chemotherapy is ultimately responsible for the majority of AML-related deaths, making the identification of resistance pathways a high priority. Transcriptomics approaches can be used to identify genes regulated at the level of transcription or mRNA stability but miss microRNA-mediated changes in translation, which are known to play a role in chemo-resistance. To address this, we compared miRNA profiles in paired chemo-sensitive and chemo-resistant subclones of HL60 cells and used a bioinformatics approach to predict affected pathways.