Publications by authors named "Paula P B Silva"
Survivin: A Potential Marker of Resistance to Somatostatin Receptor Ligands.
J Clin Endocrinol Metab
March 2023
Context: Invasive and somatostatin receptor ligand (SRL)-resistant pituitary tumors represent a challenge in the clinical practice of endocrinologists. Efforts have been made to elucidate reliable makers for both. Survivin and eukaryotic translation initiation factor-binding protein 1 (4EBP1) are upregulated in several cancers and involved in apoptosis and cell proliferation.
View Article and Find Full Text PDFImpaired Bone Microarchitecture in Premenopausal Women With Acromegaly: The Possible Role of Wnt Signaling.
J Clin Endocrinol Metab
August 2021
Context: Acromegaly can impair bone integrity, increasing the risk of vertebral fractures (VFs).
Objective: To evaluate the impact of isolated GH/IGF-I hypersecretion on bone turnover markers, Wnt inhibitors, bone mineral density (BMD), microarchitecture, bone strength and vertebral fractures in female patients with acromegaly (Acro), compared with healthy control group (HC).
Design, Setting, And Patients: Cross-sectional study including 83 premenopausal women without any pituitary deficiency:18 acromegaly in remission (AcroR), 12 in group with active acromegaly (AcroA), and 53 HC.
Bone microarchitecture and estimated bone strength in men with active acromegaly.
Eur J Endocrinol
November 2017
Context: Both acromegaly and adult growth hormone deficiency (GHD) are associated with increased fracture risk. Sufficient data are lacking regarding cortical bone microarchitecture and bone strength, as assessed by microfinite element analysis (µFEA).
Objective: To elucidate both cortical and trabecular bone microarchitecture and estimated bone strength in men with active acromegaly or GHD compared to healthy controls.
Article Synopsis
- Hypopituitarism often occurs in patients with traumatic brain injury (TBI), with about 31% of those evaluated showing at least one pituitary deficiency over a median follow-up of 40.4 months.
- The most common deficiency was growth hormone deficiency, impacting 21% of patients, while other deficiencies included central hypoadrenalism (10%), hypothyroidism (8%), and hypogonadism (12%).
- Patients who experienced motor vehicle accidents or had post-traumatic seizures, hemorrhage, or contusions were at higher risk for serious pituitary dysfunction, indicating the need for neuroendocrine testing in these cases, though some without these risk factors also developed issues.