Publications by authors named "Paul Varosy"

Background: Small studies have described the safety of uninterrupted direct oral anticoagulant (DOAC) use in atrial fibrillation (AF) patients undergoing elective, cardiac implantable electronic device (CIED) placement. Real-world practice patterns and associated outcomes remain poorly defined.

Objective: Describe DOAC usage trends following uncomplicated, outpatient CIED placement in AF patients and evaluate clinical outcomes based on DOAC status at discharge.

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Background: The Veterans Affairs (VA) Healthcare System maintains the largest integrated health system in the United States but also supports fee-for-service insurance for veterans receiving care in community facilities outside the VA. We sought to evaluate the management and outcomes of patients referred for consultation in either venue, using cardiovascular evaluation as a model.

Methods: We conducted a retrospective cohort study identifying patients enrolled in the VA Healthcare System referred for cardiovascular evaluation from October 2020 through September 2024 and stratified the population based on the venue in which evaluation was completed.

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Percutaneous catheter ablation in interventional cardiac electrophysiology has evolved over the past several decades. Technologic advances and evolving procedural strategies have improved procedural efficiencies, increased success rates, and lowered complication rates. These advances have increased the ability to treat more patients successfully; however, limitations to access have grown.

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Percutaneous catheter ablation in interventional cardiac electrophysiology has evolved over the past several decades. Technologic advances and evolving procedural strategies have improved procedural efficiencies, increased success rates, and lowered complication rates. These advances have increased the ability to treat more patients successfully; however, limitations to access have grown.

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Background: Patients undergoing atrial fibrillation (AF) ablation have historically been hospitalized overnight or longer postprocedure. National rates of same-day discharge (SDD) following AF ablation remain unknown.

Methods And Results: The NCDR (National Cardiovascular Data Registry) AF Ablation Registry was used to identify index procedures from January 1, 2016 to June 30, 2023.

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This appropriate use criteria (AUC) document is developed by the American College of Cardiology along with key specialty and subspecialty societies. It provides a comprehensive review of common clinical scenarios where implantable cardioverter-defibrillator (ICD), cardiac resynchronization therapy (CRT), cardiac contractility modulation, leadless pacing, and conduction system pacing therapies are frequently considered. The 335 clinical scenarios covered in this document address ICD indications including those related to secondary prevention, primary prevention, comorbidities, generator replacement at elective replacement indicator, dual-chamber, and totally subcutaneous ICDs, as well as device indications related to CRT, conduction system pacing, leadless pacing, cardiac contractility modulation, and ICD therapy in the setting of left ventricular assist devices (LVADs).

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Background: Myotonic dystrophy type 1 (DM1) is associated with progressive conduction disease. Furthermore, DM1 patients are at risk ventricular arrhythmias (VAs), although prediction remains difficult. The 2022 Heart Rhythm Expert Consensus Statement gives a IIb recommendation to the use of electrophysiology study (EPS) to risk-stratify patients for VAs.

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Background: Identification of patients at risk for atrial fibrillation (AF) after typical atrial flutter (tAFL) ablation is important to guide monitoring and treatment.

Objective: The purpose of this study was to create and validate a risk score to predict AF after tAFL ablation METHODS: We identified patients who underwent tAFL ablation with no AF history between 2017 and 2022 and randomly allocated to derivation and validation cohorts. We collected clinical variables and measured conduction parameters in sinus rhythm on an electrophysiology recording system (CardioLab, GE Healthcare).

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Article Synopsis
  • The National Cardiovascular Data Registry's LAAO Registry includes most LAAO procedures in the U.S., and this study aimed to create a model predicting in-hospital adverse events for patients undergoing LAAO with Watchman FLX.
  • The study analyzed data from 41,001 procedures, using logistic regression on both development and validation cohorts to identify key predictors of major adverse events, such as age, sex, and health status.
  • The resulting risk model showed moderate accuracy and offered a simplified bedside risk score, enabling healthcare professionals to better predict risks and improve decision-making in patient care.
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Introduction: During atrial fibrillation ablation (AFA), achievement of first pass isolation (FPI) reflects effective lesion formation and predicts long-term freedom from arrhythmia recurrence. We aim to determine the clinical and procedural predictors of pulmonary vein FPI.

Methods: We reviewed AFA procedures in a multicenter prospective registry of AFA (REAL-AF).

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Background: The appropriate use criteria (AUCs) are a diverse group of indications aimed to better evaluate the benefits of implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy.

Objective: The purpose of this study was to quantify the proportion of ICD and cardiac resynchronization therapy with defibrillator (CRT-D) implants as appropriate, may be appropriate (MA), or rarely appropriate (RA) on the basis of the AUC guidelines.

Methods: This is a multicenter retrospective study of patients within the National Cardiovascular Data Registry undergoing ICD implantation between April 2018 and March 2019 at >1500 US hospitals.

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Background: Among patients hospitalized for atrial fibrillation, the frequency of off-label direct oral anticoagulant (DOAC) dosing, associated factors, hospital-level variation, and temporal trends in contemporary practice are unknown.

Methods: Using the Get With The Guidelines-Atrial Fibrillation registry, patients admitted from January 1, 2014, to March 31, 2020, and discharged on DOACs were stratified according to receipt of underdosing, overdosing, or recommended dosing. Factors associated with off-label dosing (defined as underdosing or overdosing) were identified using logistic regression.

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Article Synopsis
  • The study aimed to create an easy-to-use scoring system to assess the risk of needing a permanent pacemaker (PPM) after transcatheter aortic valve replacement (TAVR).
  • Atrial block, a common issue related to TAVR, prompted the need for a more clinically applicable risk prediction model, as existing models weren't suitable for pre-procedure planning.
  • The resulting PRIME score was developed using five key pre-procedure variables and demonstrated high accuracy in predicting PPM needs in both training and validation groups.
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Remote monitoring is beneficial for the management of patients with cardiovascular implantable electronic devices by impacting morbidity and mortality. With increasing numbers of patients using remote monitoring, keeping up with higher volume of remote monitoring transmissions creates challenges for device clinic staff. This international multidisciplinary document is intended to guide cardiac electrophysiologists, allied professionals, and hospital administrators in managing remote monitoring clinics.

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Remote monitoring is beneficial for the management of patients with cardiovascular implantable electronic devices by impacting morbidity and mortality. With increasing numbers of patients using remote monitoring, keeping up with higher volume of remote monitoring transmissions creates challenges for device clinic staff. This international multidisciplinary document is intended to guide cardiac electrophysiologists, allied professionals, and hospital administrators in managing remote monitoring clinics.

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Article Synopsis
  • The study analyzed data from over 52,000 patients diagnosed with atrial fibrillation between 2010 and 2020 to determine the best rhythm-management strategies for individuals.
  • Researchers utilized a form of artificial intelligence called tabular Q-learning to predict optimal treatments based on outcomes such as mortality and treatment sustainability, while also clustering patients into distinct groups for better analysis.
  • Findings revealed that rhythm-control strategies led to better outcomes than rate-control strategies, particularly when the treatment matched the Q-learning recommendations, indicating a promising method for improving clinical decision-making in atrial fibrillation management.
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Background: The National Cardiovascular Data Registry (NCDR) AFib Ablation Registry was created to assess real-world prevalence, demographic characteristics, procedural management, and outcomes of patients undergoing atrial fibrillation (AF) ablation procedures.

Objectives: The goal of this study was to characterize the patient, hospital, and physician characteristics and in-hospital outcomes related to AF ablation in the first 5 years of the registry.

Methods: This paper describes the AFib Ablation Registry structure and governance, outcome assessment processes, data quality, and data collection processes.

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Article Synopsis
  • Esophageal injury is a recognized risk during catheter ablation procedures, and new methods to reduce this risk are being evaluated through temperature gradient studies.
  • Researchers conducted experiments using a porcine heart model to analyze how different ablation techniques affected temperature changes in the left atrium and surrounding tissues, specifically focusing on the esophagus.
  • Results showed that standard ablation techniques resulted in a significantly higher temperature increase at the anterior wall of the esophagus compared to high-power short duration approaches, indicating potential risks with different methods.
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Atrial fibrillation (AF) represents a significant health care burden in the United States that will continue to increase as the population ages; thus, the introduction of cost-effective strategies to limit this burden is critical. The establishment of dedicated electrophysiology programs focusing on AF care within hospitals can improve patient care while providing added financial benefits for institutions if properly planned and delivered. This paper explains how to develop an efficient and quality-focused AF ablation program as part of a larger AF center of excellence by highlighting the experience of a single center and demonstrating how the same principles were adopted to implement a similar program at another institution.

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Article Synopsis
  • Left atrial appendage occlusion is a viable alternative to anticoagulation for patients with nonvalvular atrial fibrillation, yet device sizing and complications in real-world use needed further analysis.
  • A study using the NCDR LAAO Registry examined the outcomes of patients receiving Watchman 2.5 devices, categorizing them as undersized, oversized, or per manufacturer recommendations.
  • Findings revealed that a significant portion of patients received oversized devices, which were associated with lower odds of complications like leakage compared to manufacturers' sizing, and the preference for oversized devices increased over the study period.
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Background: Shared decision making (SDM) is gaining importance in cardiology, including Centers for Medicare & Medicaid Services (CMS) reimbursement policies requiring documented SDM for patients considering primary prevention implantable cardioverter defibrillators. The DECIDE-ICD Trial (Decision Support Intervention for Patients offered implantable Cardioverter-Defibrillators) assessed the implementation and effectiveness of patient decision aids (DAs) using a stepped-wedge design at 7 sites. The purpose of this subanalysis was to qualitatively describe electrophysiology clinicians' experience implementing and using the DAs.

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