Publications by authors named "Paul Philipp Heinisch"

Objectives: Acute kidney injury commonly complicates congenital heart surgery with cardiopulmonary bypass, increasing morbidity and mortality. This study aimed to evaluate risk factors for postoperative acute kidney injury and its impact on outcomes after the Norwood procedure.

Methods: Neonates undergoing the Norwood procedure from 2001 to 2022 were reviewed.

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Objective: Current research suggests that a small pulmonary artery can cause adverse events and reduce exercise capacity after the Fontan procedure. This study aimed to evaluate the impact of pulmonary artery size on early haemodynamic and laboratory variables after total cavopulmonary connection.

Methods: We reviewed all patients who underwent staged Fontan between 2012 and 2022.

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Objectives: This study aimed to investigate the impact of left pulmonary artery stenting on outcomes after Fontan procedure in patients with single ventricle physiology.

Methods: Patients who underwent staged Fontan palliation between 1994 and 2023 were reviewed. The records of patients who had left pulmonary artery stents implanted were analysed, and their impact on outcomes after Fontan completion was evaluated.

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Objective: Thrombus formation is a feared complication after congenital heart surgery. We aimed to clarify the clinical characteristics associated with thrombus formation after the Norwood procedure.

Methods: All neonates who underwent the Norwood procedure between 2001 and 2022 were reviewed.

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Objective: The clinical significance of left ventricular rehabilitation for borderline left ventricular hypoplasia is controversial. This study aimed to review the surgical results of patients with borderline left ventricular hypoplasia and to evaluate the impact of left ventricular rehabilitation on outcomes.

Methods: Patients diagnosed with borderline left ventricular hypoplasia and surgically treated from 2018 to 2022 were included.

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Objectives: This study aimed to investigate the benefits and potential risks of implantable cardioverter-defibrillators in paediatric and congenital heart disease (CHD) patients in the current era.

Methods: All patients with CHD, paediatric cardiomyopathy or primary electrical disease, who underwent implantation of a defibrillator from 2001 to 2023, were examined. The occurrence of appropriate therapy, unplanned surgeries due to device complications, inappropriate shocks and associated risk factors were analysed.

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BackgroundMinimally invasive thoracotomies to repair selected congenital heart defects are considered only a cosmetic alternative approach by many; however, they represent the routine alternative in centers of expertise.MethodsPooled institutional data from the European Congenital Heart Surgeons Association using mini-thoracotomy approaches were analyzed since the beginning of their respective experiences until an inclusion surgical date of January 31, 2024, allowing at least six months postoperative follow-up.ResultsFrom 1999 to 2024, 3,007 patients from 11 centers underwent surgery.

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Objectives: Biventricular repair (BVR) for patients with borderline hypoplastic left ventricle is challenging, and a predictor of failing BVR has not been clarified. This study aimed to analyse the z-log N-terminal pro-B-type natriuretic peptide and evaluate its usefulness in predicting outcomes after BVR.

Methods: Patients who were diagnosed with borderline left heart hypoplasia and underwent BVR from 2012 to 2022 were included.

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Objectives: This study aimed to investigate the incidence of diaphragm paralysis and its impact on outcomes after the Fontan procedure in patients with single ventricles.

Methods: Patients undergoing staged Fontan palliation between 1994 and 2023 were reviewed. Patients who had diaphragm paralysis were identified, and the impact of diaphragm paralysis on outcomes after Fontan completion was evaluated.

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Background: Evaluation of the impact of 3D-printed models on parental education and anxiety in parents of children with congenital heart disease (CHD) who are undergoing interventions or surgeries.

Methods: A prospective randomized controlled trial was conducted at LMU University Hospital and the German Heart Center Munich. Parents (n = 57) of pediatric CHD patients were randomized into two groups: a control group using standardized paper-based methods and an intervention group using additional 3D-printed models.

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Objectives: This study aimed to evaluate the relationship between pulmonary artery size and venovenous collaterals (VVCs) during staged single ventricle reconstruction.

Methods: Patients who underwent staged Fontan palliation between 2003 and 2023 were reviewed. The relationship between the pulmonary artery index and the development of VVCs was determined.

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Objective: Despite advancements in surgical techniques, many patients born with congenital heart defects (CHD) require repeated reinterventions due to the limitations of materials used in congenital cardiac surgery (CCS). Traditional biogenic polymers, such as bovine or equine pericardium, are prone to calcification, have limited durability, and fail to adapt to the growth of infants. This study aims to address these challenges by investigating bacterial cellulose (BC) as a promising material for CCS.

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Objectives: We aimed to determine the incidence of postoperative complete atrioventricular block, the time to recovery or permanent pacemaker implantation and the predictors for postoperative atrioventricular block after congenital heart surgery.

Methods: Patients who underwent open-heart surgery from January 2001 to January 2024 were analysed and predictors of atrioventricular block were identified using a logistic regression model.

Results: Among 9765 congenital heart surgeries, 333 (3.

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Objective: We aimed to evaluate outcomes after Kawashima procedure with special regard to the development of pulmonary arterio-venous malformations.

Methods: All patients who underwent Kawashima procedure between 1992 and 2022 were reviewed.

Results: Twenty-one patients underwent Kawashima procedure at a median age of 14.

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Background: Aortic atresia (AA) is considered a risk for the Norwood procedure. This study aimed to compare the longitudinal ventricular function (VF) and atrioventricular valve (AVV) regurgitation in patients with AA and aortic stenosis (AS).

Methods: Using serial echocardiographic images in patients undergoing the neonatal Norwood procedure between 2001 and 2020, systemic VF assessed by ejection fraction and the degree of AVV regurgitation were compared between the patients with AA and AS.

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Objective: This study aimed to evaluate veno-venous collaterals between bidirectional cavopulmonary shunt and total cavopulmonary connection.

Methods: Patients who underwent staged total cavopulmonary connection between 1995 and 2022 were reviewed. Veno-venous collaterals between bidirectional cavopulmonary shunt and total cavopulmonary connection were depicted using angiograms.

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Objectives: This study investigated the longitudinal changes in ventricular function and atrioventricular valve function to clarify the timing and the mechanisms of failing Fontan.

Methods: Patients who underwent total cavopulmonary connection between 1994 and 2023 were reviewed, and longitudinal echocardiographic examinations of ventricular function and atrioventricular valve regurgitation were analysed.

Results: A total of 650 patients were included.

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Objective: To investigate the long-term impact of cardiac surgery on the quality of life in adults with congenital heart disease (ACHDs).

Methods: Patients who had undergone cardiac surgery for congenital heart disease (CHD) at the age of 18 years or more were recruited in a single-center, cross-sectional study. The enrolled subjects completed online questionnaires to assess patient-reported outcomes: perceived health status and life satisfaction, psychological functioning, health behaviors, and illness perception.

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Objective: This study aims to assess the surgical outcome of borderline hypoplastic left ventricle before and after the induction of the left ventricle rehabilitation strategy.

Methods: A retrospective review investigated patients with borderline hypoplastic left ventricle who underwent surgical intervention between 2012 and 2022. The patient cohort was stratified into two groups based on the initiation of left ventricle rehabilitation: an early-era group (E group, 2012-2017) and a late-era group (L group, 2018-2022).

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Article Synopsis
  • The study investigates the link between aorto-pulmonary and veno-venous collaterals and the development of plastic bronchitis in patients following the Fontan procedure from 1994 to 2022.
  • Out of 635 patients analyzed, 15 (2.4%) developed plastic bronchitis, with those affected showing significantly higher rates of aorto-pulmonary (60% vs. 14%) and veno-venous collaterals (53% vs. 14%).
  • Findings suggest that managing these collaterals could help prevent plastic bronchitis, which poses added health risks for patients post-Fontan procedure.
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Article Synopsis
  • The study compared pulmonary artery growth in infants with univentricular hearts who received ductus stenting (DS) versus those who had a systemic to pulmonary shunt (SPS) for initial palliation from 2009 to 2022.
  • A total of 130 infants were evaluated, revealing that while most pulmonary artery metrics were similar between groups, the DS group had a significantly lower left pulmonary artery index and a higher occurrence of veno-venous collaterals compared to the SPS group.
  • The findings suggest that infants after DS are more likely to need further pulmonary artery interventions between stages II and III palliation, highlighting the need for further investigation into long-term outcomes after the Fontan procedure
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Objective: We have left antegrade pulmonary blood flow (APBF) at bidirectional cavopulmonary shunt (BCPS) only for high-risk patients. This study evaluates the indication and the outcomes of patients with APBF, compared to those without APBF.

Methods: Patients with APBF after BCPS were identified among patients who underwent BCPS between 1997 and 2022.

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Article Synopsis
  • The study investigates the effects of low birth weight on outcomes for patients undergoing staged palliation for single ventricle heart conditions.
  • It found that patients with low birth weight (2.5 kg or less) had higher mortality rates and were less likely to progress to further stages of treatment compared to those with normal weight.
  • The findings suggest that low birth weight significantly negatively impacts survival rates even five years post-treatment, emphasizing the need for closer monitoring of these at-risk patients throughout their care.
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Article Synopsis
  • The EUROMACS study aimed to explore how the annual number of LVAD implantations at a medical center affects postoperative outcomes and patient survival.
  • It analyzed data from 4,802 patients across 35 centers, categorizing them based on whether the center performed 30 or fewer vs. more than 30 implants per year, focusing on 1-year survival rates and device-related complications.
  • Findings indicated that while higher volume centers had patients with more severe conditions, there was no significant difference in 1-year survival; however, higher volume centers had more device-related adverse events, highlighting the need for consistent quality improvement across all centers.
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