Publications by authors named "Patricia V Teixeira"
Lyotropic liquid crystalline 2D and 3D mesophases: Advanced materials for multifunctional anticancer nanosystems.
Biochim Biophys Acta Rev Cancer
November 2023
Cancer remains a leading cause of mortality. Despite significant breakthroughs in conventional therapies, treatment is still far from ideal due to high toxicity in normal tissues and therapeutic inefficiency caused by short drug lifetime in the body and resistance mechanisms. Current research moves towards the development of multifunctional nanosystems for delivery of chemotherapeutic drugs, bioactives and/or radionuclides that can be combined with other therapeutic modalities, like gene therapy, or imaging to use in therapeutic screening and diagnosis.
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- Cancer is projected to cause more deaths in the coming decades despite advances in treatment, which face issues like lack of selectivity and multidrug resistance.
- Current research is exploring combined therapy using natural compounds alongside traditional chemotherapeutics or nucleic acids to enhance treatment effectiveness.
- The review highlights how lipid-based nanocarriers can improve the delivery of these agents, emphasizing their potential to reduce resistance and toxicity while addressing challenges for clinical application in cancer treatment.
Current needs for increased drug delivery carrier efficacy and specificity in cancer necessitate the adoption of intelligent materials that respond to environmental stimuli. Therefore, we developed and optimized pH-triggered drug delivery nanoassemblies that exhibit an increased release of doxorubicin (DOX) in acidic conditions typical of cancer tissues and endosomal vesicles (pH 5.5) while exhibiting significantly lower release under normal physiological conditions (pH 7.
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