Publications by authors named "Patric B Mark"
Br J Pharmacol
September 2024
Article Synopsis
- The study focuses on the ryanodine receptor 2 (RyR2), which is important for calcium regulation in the heart and kidneys, and investigates the effects of the drug M201-A on these organs.
- M201-A was tested both in preclinical studies with rat heart cells and animals, as well as in clinical trials with healthy males, monitoring its impact on calcium leakage, cardiac function, and renal performance.
- Results indicate that M201-A effectively reduces calcium leakage in heart cells, improves heart function, and enhances kidney function in both animal models and human subjects, suggesting it could be a new treatment for chronic kidney disease and heart failure.
