Publications by authors named "Patience Castleton"

Migration exposes people to unfamiliar gender roles and sexual views, influencing the ways they care for their sexual and reproductive health (SRH). Migrant men's health is overlooked in care and research, prohibiting culturally responsive care that acknowledges these changing beliefs. Thus, we aimed to synthesise the available evidence on the ways pre-established gender norms impact a man's SRH in the setting of migration to a high-income country.

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The adolescent years are pivotal in reproductive and sexual development and maturation, yet the experience of migration can severely disrupt this period, inhibiting young immigrants' knowledge, access, and engagement with sexual and reproductive health (SRH) services. Further, young immigrants and minority populations often face persistent intersectional barriers, including language difficulties, cultural stigma, and systemic exclusion, that result in adverse SRH outcomes. Recent advances in SRH care, particularly in digital health and community-based interventions, show promise in improving access to culturally appropriate SRH services and information.

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Background: Adolescents make up to 23% of Pakistan's population, yet they face significant barriers to accessing sexual and reproductive health (SRH) knowledge and services. These challenges stem from systemic and individual factors, including cultural norms and low health literacy. This project aims to directly involve adolescents and key stakeholders in the co-development of a culturally relevant SRH toolkit to improve access to accurate information.

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Objective: To identify gaps in existing evidence on preconception health interventions to improve the health outcomes of adolescents, young adults, and their offspring.

Study Design: Evidence gap map (EGM) METHODS: Following the Campbell guidelines, we included reviews and interventional studies identified through searches on Medline and other electronic databases from 2010 to July 18th, 2023. Dual screening of titles/abstracts and full texts was conducted on Covidence software, followed by quality assessment and development of 2D-EGM using the EPPI-Reviewer and Mapper software.

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Introduction: Adolescence is a crucial stage of physical and sexual maturation and development and a period in which understanding sexual and reproductive health (SRH) is important. SRH interventions and toolkits provide a range of valuable resources and information to young people, educators, and members of the community on numerous topics, including contraception and puberty.

Objectives: The usefulness and reliability of these available toolkits have not been previously studied, thus limiting our understanding of their appropriateness and contents.

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Background: Preconception health provides an opportunity to examine a woman's health status and address modifiable risk factors that can impact both a woman's and her child's health once pregnant. In this review, we aimed to investigate the preconception risk factors and interventions of early pregnancy and its impact on adverse maternal, perinatal and child health outcomes.

Methods: We conducted a scoping review following the PRISMA-ScR guidelines to include relevant literature identified from electronic databases.

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Purpose: Semen parameters are subjected to within-individual variability over time. The driving factors for this variability are likely multi-factorial, with healthier lifestyle associated with better semen quality. The extent in which variations in individual's lifestyle contributes to within-individual semen variability is unknown.

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Background: Oxidative stress in semen contributes up to 80% of all infertility diagnosis. Diagnostics to measure oxidative stress in semen was recently added to the 6th edition WHO methods manual, although diagnostic predictive values need to be interpreted with caution as there are still several research questions yet to be answered.

Objectives: To determine the natural fluctuations in semen redox indicators (MiOXSYS and OxiSperm II) within and between men and their association with markers of sperm oxidative stress.

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Oxidative stress and elevated levels of seminal and sperm reactive oxygen species (ROS) may contribute to up to 80% of male infertility diagnosis, with sperm ROS concentrations at fertilization important in the development of a healthy fetus and child. The evaluation of ROS in semen seems promising as a potential diagnostic tool for male infertility and male preconception care with a number of clinically available tests on the market (MiOXSYS, luminol chemiluminescence and OxiSperm). While some of these tests show promise for clinical use, discrepancies in documented decision limits and lack of cohort studies/clinical trials assessing their benefits on fertilization rates, embryo development, pregnancy and live birth rates limit their current clinical utility.

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