Publications by authors named "Pasquale Annese"

Despite surgical advancements, erectile dysfunction (ED) is a common consequence of radical prostatectomy (RP). This study aimed to evaluate the impact of early penile rehabilitation within a dedicated penile rehabilitation program on assisted and unassisted erectile function (EF) recovery. All patients who underwent RP and at least 1 year follow-up at penile rehabilitation program in the Department of Urology, OORR Policlinico Riuniti (Foggia, Italy) were included.

View Article and Find Full Text PDF

Purpose: Prostatic urethral lift has been an effective ejaculation sparing treatment for benign prostatic hypertrophy. The aim of this study was to evaluate the effect on male semen parameters.

Methods: Between July 2014 and January 2022, 20 young men with urinary symptoms of BPH, unresponsive to drug treatment and motivated to preserve ejaculation for eventual paternity, underwent UroLift.

View Article and Find Full Text PDF

Previous published studies have shown an improvement of penile hemodynamic parameters after low-intensity extracorporeal shockwave therapy (Li-ESWT). However, the clinical significance of these findings remains unclear, and definitive selection criteria for Li-ESWT based on preexisting comorbidities have yet to be established. This was an observational study of 113 patients with ED, evaluated between January 2019 and December 2021 in Andrology Unit at the Department of Urology and Renal Transplantation, University of Foggia (Foggia, Italy).

View Article and Find Full Text PDF

Oxidative stress is one of the main mechanisms responsible for male infertility. Various conditions such as varicocele, obesity, advanced age, and lifestyle can lead to an increase in reactive oxygen species, causing an oxidative imbalance in the reproductive environment. Spermatozoa are sensitive to reactive oxygen species and require energy to carry out their main function of fertilizing the egg.

View Article and Find Full Text PDF
Article Synopsis
  • Inflatable penile prostheses are recognized as the best treatment for erectile dysfunction, with two main surgical techniques: penoscrotal and infrapubic, though no definitive evidence shows one is better than the other.
  • A review of 26 studies indicates that while the penoscrotal approach is more common and viewed as comfortable by surgeons, the infrapubic method is quicker and results in higher patient satisfaction.
  • Overall, both techniques show similar complication rates, with the choice often depending on case complexity and surgeon preference, despite the infrapubic method's advantages in speed and patient contentment.
View Article and Find Full Text PDF

The increasing importance of treatment of lower urinary tract symptoms (LUTS), while avoiding side effects and maintaining sexual function, has allowed for the development of minimally invasive surgical therapies (MISTs). Recently, the European Association of Urology guidelines reported a paradigm shift from the management of benign prostatic hyperplasia (BPH) to the management of nonneurogenic male LUTS. The aim of the present review was to evaluate the efficacy and safety of the most commonly used MISTs: ablative techniques such as aquablation, prostatic artery embolization, water vapor energy, and transperineal prostate laser ablation, and nonablative techniques such as prostatic urethral lift and temporarily implanted nitinol device (iTIND).

View Article and Find Full Text PDF

Risk calculator (RC) combining PSA with other clinical information can help to better select patients at risk of prostate cancer (PCa) for prostate biopsy. The present study aimed to develop a new Pca RC, including MRI and bladder outlet obstruction parameters (BOOP). The ability of these parameters in predicting PCa and clinically significant PCa (csPCa: ISUP GG ≥ 2) was assessed by binary logistic regression.

View Article and Find Full Text PDF

Background: Radical prostatectomy is considered the gold-standard treatment for patients with localized prostate cancer. The literature suggests there is no difference in oncological and functional outcomes between robotic-assisted radical prostatectomy (RARP) and open (RRP). (2) Methods: The aim of this study was to compare continence recovery rates after RARP and RRP measured with 24 h pad weights and the International Consultation on Incontinence Questionnaire—Short Form (ICIQ-SF).

View Article and Find Full Text PDF
Article Synopsis
  • Traditional diagnosis and staging of prostate cancer rely on PSA levels, digital rectal exams, and ultrasound-guided biopsies, but biomarkers have emerged to improve accuracy and reduce unnecessary treatments.
  • A review indicated there are 13 notable biomarkers that can guide decisions on biopsy, treatment necessity, and identifying high-risk patients post-surgery.
  • Despite their availability and potential benefits, these biomarkers aren't widely used in practice due to insufficient direct comparisons and unproven long-term effectiveness.
View Article and Find Full Text PDF
Article Synopsis
  • Sacrocolpopexy (SC) is a surgical treatment for pelvic organ prolapse (POP), but there's uncertainty about whether to use mesh on both the anterior and posterior vaginal walls in minor cases of posterior prolapse.
  • This study analyzed data from 95 women who underwent SC, comparing outcomes between those receiving only anterior mesh and those receiving both anterior and posterior mesh.
  • Results showed no significant differences in anatomical or functional recovery between the two groups, though some complications were noted in both surgical methods.
View Article and Find Full Text PDF

Background And Aims: Prostatic urethral lift (Urolift™) is a minimally invasive technique to treat male lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH). The aim of the present study was to assess safety and medium- to long-term outcomes in the relief of urinary symptoms.

Methods: We included 35 men, affected by severe symptomatic BPH evaluated by International Prostate Symptom Score (IPSS), with normal erectile function (EF) and ejaculatory function (EjF) evaluated by the International Index of Erectile Dysfunction (IIEF-5) and Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EjD-SF).

View Article and Find Full Text PDF

Distal ureter bladder cuff (DUBC) excision is an essential part of radical nephroureterectomy (RNU), but the technique to accomplish it remains controversial. We describe a novel technique of transurethral distal ureter balloon occlusion before detachment (TUDUBOD) whereby the affected ureter is occluded with a 5F Fogarty balloon catheter and circumferentially incised until the perivesical fat to detach it from the bladder. In the 13 patients who were treated between May 2005 and May 2010, mean surgical time for TUDUBOD was 21.

View Article and Find Full Text PDF
Article Synopsis
  • The study focused on the prognostic value of p53 and retinoblastoma protein (pRb) expressions in patients with stage T1 grade 3 bladder cancer undergoing BCG treatment.
  • Sixteen tumors had altered p53 levels and 14 had altered pRb levels; only altered pRb was found to independently predict cancer recurrence and progression.
  • The findings suggest that these markers could help guide treatment decisions for bladder cancer patients and should be validated in future studies.
View Article and Find Full Text PDF

Urethral amyloidosis is a rare, probably inflammatory condition usually presenting with hematuria and obstructive urinary symptoms, thus mimicking urethral malignancy. After histological confirmation of the diagnosis, treatment can be expectant or symptomatic. AIM.

View Article and Find Full Text PDF

Objectives: Bacillus Calmette-Guérin (BCG) immunotherapy is regarded as the current treatment of choice for stage T1 grade 3 (T1G3) bladder cancer (BC), though its efficacy is limited by high recurrence and progression rate. Identification of molecular prognosticators that might be helpful in discriminating between responders and nonresponders to BCG treatment is therefore of major clinical importance; thus we focused on the cell-cycle related retinoblastoma protein (pRB), which had been already investigated in bladder cancer. The goal of our study was specifically to address whether its expression predicts the outcomes of BCG treatment for patients with T1G3 disease.

View Article and Find Full Text PDF

Introduction: Percutaneous nephrostomy has traditionally been performed with the patient in the prone position, probably to reduce the risk of injury to adjacent visceral organs, particularly the colon. The prone position, however, is associated with disadvantages such as patient discomfort and circulatory and ventilatory difficulties, particularly in obese patients. We describe a technique of percutaneous nephrostomy with the patient in the supine anterolateral position using local anesthesia, ultrasound-guided puncture, and fluoroscopy-controlled placement.

View Article and Find Full Text PDF

Leiomyoma is a benign neoplasm rarely found in the bladder. We present a case of a large leiomyoma of the bladder treated successfully by endoscopic transurethral resection.

View Article and Find Full Text PDF