Atrial cardiomyocyte-restricted cleavage of gasdermin D promotes atrial arrhythmogenesis.

Background And Aims: Enhanced inflammatory signalling causally contributes to atrial fibrillation (AF) development. Gasdermin D (GSDMD) is an important downstream effector of several inflammasome pathways. However, the role of GSDMD, particularly the cleaved N-terminal (NT)-GSDMD, in non-immune cells remains elusive.