Publications by authors named "Pascal L M L Wielders"
Article Synopsis
- Prednisone is the first-line treatment for pulmonary sarcoidosis but comes with several side effects, while methotrexate is the second-line option with fewer side effects but slower action.
- A noninferiority trial involving 138 patients compared the effects of prednisone and methotrexate on lung function at 24 weeks, finding that methotrexate's efficacy was comparable to that of prednisone.
- Both treatment groups experienced similar adverse events, with prednisone leading to weight gain and insomnia, while methotrexate was associated with nausea and fatigue.
Background: The relationship between inhaled corticosteroids and bone mineral density (BMD) remains uncertain despite extensive research.
Methods: This was an international, multicenter, randomized, double-blind, parallel-group, 3-year noninferiority study. Patients with chronic obstructive pulmonary disease (COPD) (⩾40 years of age; smoking history ⩾10 pack years) and at least one native hip evaluable for BMD were enrolled and randomized 1:1, stratified by sex, to treatment with vilanterol (VI) 25 µg or fluticasone furoate/vilanterol (FF/VI) 100 µg/25 µg.
ERS Congress highlight: educational forum on continuing professional development.
Breathe (Sheff)
June 2018
http://ow.ly/hP9k30kz6ZM.
View Article and Find Full Text PDFGSK961081 is a bifunctional molecule demonstrating both muscarinic antagonist and β-agonist activities. This was a 4-week, multicentre, randomised, double-blind, double-dummy, placebo and salmeterol controlled parallel group study. Doses ranging across three twice-daily doses and three once-daily doses were assessed in moderate and severe chronic obstructive pulmonary disease (COPD) patients.
View Article and Find Full Text PDFArticle Synopsis
- Dry powder devices are seldom used in ER settings for acute bronchoconstriction due to concerns about their effectiveness.
- This study compared the efficacy of two inhalers (Turbuhaler vs. pMDI+S) delivering formoterol for patients experiencing severe dyspnoea from COPD exacerbations.
- Results indicated that both inhalers produced nearly identical improvements in lung function (FEV(1)) and shortness of breath scores, confirming that Turbuhaler is as effective as the pMDI+S in treating acute bronchoconstriction in the ER.
Background: COPD is characterized by episodic increases in respiratory symptoms, so-called exacerbations. COPD exacerbations are associated with an increase in local and systemic inflammation. Data of a previously published study in a well-characterized COPD cohort were analyzed to define predictive factors of acute exacerbations, particularly focusing on systemic inflammation.
View Article and Find Full Text PDFSurgical mediastinal staging in daily practice.
Lung Cancer
February 2005
Study Objectives: An adequately staged mediastinum remains obligatory in patients with NSCLC prior to surgery. In this study, we investigated the accuracy of preoperative surgical mediastinal staging procedures in four hospitals.
Setting: Non-university teaching hospital and three surrounding community hospitals in Eindhoven, The Netherlands.