Publications by authors named "Pascal B Kunz"
A major challenge in the glycosciences is the scarcity of sensitive and specific glycan-binding reagents, such as monoclonal antibodies, for detecting and isolating glycans. Here we report the development and characterization of new monoclonal antibodies (mAbs) that bind carbohydrate-based red blood cell (RBC) antigens including the ABO(H) antigens. This approach exploits the immune system of the sea lamprey (Petromyzon marinus), which strongly responds to human glycans to enable the generation of high affinity antibodies.
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- Intrathecal drug administration is a promising method for delivering biologics to the central nervous system (CNS), but there is limited knowledge on how well intrathecally applied antibodies are tolerated and their pharmacokinetics.
- This study involved administering a human monoclonal antibody against Nogo-A to non-human primates, assessing toxicity, pharmacokinetics, and pharmacodynamics with no observed side effects, indicating good tolerability.
- Findings showed that the antibody was rapidly cleared from the cerebrospinal fluid but accumulated in the serum, effectively targeting Nogo-A in the CNS, which could enhance therapeutic strategies for CNS diseases.