Publications by authors named "Parisa Honarpisheh"
Recent studies have highlighted the crucial role of microglia (MG) and their interactions with the gut microbiome in post-stroke neuroinflammation. The activation of immunoregulatory pathways, including the aryl hydrocarbon receptor (AHR) pathway, is influenced by a dynamic balance of ligands derived from both the host and microbiota. This study aimed to investigate the association between stroke-induced dysbiosis and the resultant imbalance in AHR ligand sources (loss of microbiota-derived [indole-based] and increase of host-derived [kynurenine-based]) after stroke.
View Article and Find Full Text PDFArticle Synopsis
- Stroke is a significant health issue, especially for older adults, with limited treatments currently available; however, research suggests that the gut microbiome might influence inflammation in the brain after a stroke through the aryl hydrocarbon receptor (AHR) pathway.
- Microglia, the brain's immune cells, play a crucial role in managing post-stroke inflammation, and the activation of AHR by different ligands from the body or microbiome can have opposing effects on recovery.
- The study aims to understand how stroke changes gut bacteria and the impact of these changes on AHR ligands, hypothesizing that restoring the balance between harmful and beneficial ligands could improve outcomes after a stroke.
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary kidney disease that can affect several organs. The clinical course of the disease varies among patients; some never become symptomatic, and others reach end-stage kidney disease (ESKD) in the 5th decade of their life.
Methods: This historical cohort study was conducted on ADPKD patients to investigate kidney and patient survival rates and related risk factors in Iran.
Fixed drug eruption after the Sinopharm COVID-19 vaccine.
JEADV Clin Pract
June 2022
After coronavirus disease 2019 (COVID-19) became widespread around the world, several vaccines have been developed with variable efficacy and potency and based on different platforms to control the pandemic. One of these vaccines is Sinopharm (BBIBP-CorV), which is an inactivated virus that was released by Sinopharm's Beijing institute in the summer of 2020. The most commonly reported side effects of the Sinopharm vaccine have included pain at the injection site, muscle pain, headache and fatigue.
View Article and Find Full Text PDFRecent studies have highlighted the deleterious contributions of B cells to post-stroke recovery and cognitive decline. Different B cell subsets have been proposed on the basis of expression levels of transcription factors (e.g.
View Article and Find Full Text PDFBackground: The ability to distinguish resident microglia from infiltrating myeloid cells by flow cytometry-based surface phenotyping is an important technique for examining age-related neuroinflammation. The most commonly used surface markers for the identification of microglia include CD45 (low-intermediate expression), CD11b, Tmem119, and P2RY12.
Methods: In this study, we examined changes in expression levels of these putative microglia markers in in vivo animal models of stroke, cerebral amyloid angiopathy (CAA), and aging as well as in an ex vivo LPS-induced inflammation model.