Publications by authors named "Pamela A Chansky"
Novel cellular therapies may enable HIV control or cure. HIV-specific T cells targeting conserved immunogenic protein regions of HIV Gag/Pol and the entirety of HIV Nef, termed HST-NEETs, eliminate HIV infected cells in vitro. Here we enroll seven participants in an open-label, single-arm phase 1 study (NCT03485963) to evaluate the safety (primary endpoint) of two autologous administrations of HST-NEET products without prescribed lymphodepletion.
View Article and Find Full Text PDFDatamining approaches for examining the low prevalence of N-acetylglutamate synthase deficiency and understanding transcriptional regulation of urea cycle genes.
Ljubica Caldovic
,
Julie J Ahn
,
Jacklyn Andricovic
,
Veronica M Balick
,
Mallory Brayer
,
Pamela A Chansky
J Inherit Metab Dis
November 2024
Article Synopsis
- * NAGS deficiency (NAGSD) is a rare urea cycle disorder that can be effectively treated with N-carbamylglutamate (NCG), and the study focused on factors that could contribute to the rarity of NAGSD, such as low genomic variation and alternative NAG sources.
- * Researchers discovered a novel regulatory element in the NAGS gene and identified new regulatory elements in other urea cycle genes, which