Publications by authors named "Pablo Camacho-Zamora"
Impact of chromosomally encoded resistance mechanisms and transferable β-lactamases on the activity of cefiderocol and innovative β-lactam/β-lactamase inhibitor combinations against Pseudomonas aeruginosa.
Lucía González-Pinto
,
Isaac Alonso-García
,
Tania Blanco-Martín
,
Pablo Camacho-Zamora
,
Pablo Arturo Fraile-Ribot
J Antimicrob Chemother
October 2024
Objectives: We aimed to compare the stability of the newly developed β-lactams (cefiderocol) and β-lactam/β-lactamase inhibitor combinations (ceftazidime/avibactam, ceftolozane/tazobactam, aztreonam/avibactam, cefepime/taniborbactam, cefepime/zidebactam, imipenem/relebactam, meropenem/vaborbactam, meropenem/nacubactam and meropenem/xeruborbactam) against the most clinically relevant mechanisms of mutational and transferable β-lactam resistance in Pseudomonas aeruginosa.
Methods: We screened a collection of 61 P. aeruginosa PAO1 derivatives.
Article Synopsis
- The study examines how social restrictions and different variants, specifically Alpha, Delta, and Omicron-BA.1, affected the spread of SARS-CoV-2 in Galicia, Spain.
- Using genomic data and mobility statistics, the research found that initial variant introductions mostly came from other Spanish regions and France, later shifting to include imports from Portugal and the U.S.
- Despite the number of introductions, most did not contribute significantly to the pandemic's evolution in Galicia, but major coastal cities were identified as key areas for viral transmission.
Article Synopsis
- The study investigates how social restrictions and different variants, specifically Alpha, Delta, and Omicron, affected SARS-CoV-2 transmission in Galicia, Spain.
- Using genomic data and mobility information, the research shows that the Alpha variant initially spread from other Spanish regions and France, while later variants saw increased influences from Portugal and the USA.
- Key coastal cities in Galicia were identified as significant hubs for the virus's dissemination, underscoring the importance of regional connectivity for public health strategies.
Interplay between OXA-10 β-Lactamase Production and Low Outer-Membrane Permeability in Carbapenem Resistance in Enterobacterales.
Isaac Alonso-García
,
Juan Carlos Vázquez-Ucha
,
Marta Martínez-Guitián
,
Cristina Lasarte-Monterrubio
,
Salud Rodríguez-Pallares
,
Pablo Camacho-Zamora
Antibiotics (Basel)
June 2023
Article Synopsis
- The study investigates the role of OXA-10 class D β-lactamase in contributing to carbapenem resistance in Enterobacterales, which was previously unclear.
- Whole genome sequencing revealed two clinical isolates with a similar genetic background that both produced OXA-10 and showed mutations in porin genes, influencing their resistance.
- The findings suggest that OXA-10 enhances carbapenem resistance, especially when combined with porin deficiencies, highlighting the importance of monitoring this enzyme in future clinical settings.