Microglia-to-neuron signaling links and inflammation to enhanced neuronal lipid metabolism and network activity.

Microglia regulate neuronal circuit plasticity. Disrupting their homeostatic function has detrimental effects on neuronal circuit health. Neuroinflammation contributes to the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), with several microglial activation genes linked to increased risk for these conditions.

Domain-Specific Pretraining of NorDeClin-Bidirectional Encoder Representations From Transformers for Code Prediction in Norwegian Clinical Texts: Model Development and Evaluation Study.

Background: Accurately assigning ICD-10 (International Statistical Classification of Diseases, Tenth Revision) codes is critical for clinical documentation, reimbursement processes, epidemiological studies, and health care planning. Manual coding is time-consuming, labor-intensive, and prone to errors, underscoring the need for automated solutions within the Norwegian health care system. Recent advances in natural language processing (NLP) and transformer-based language models have shown promising results in automating ICD (International Classification of Diseases) coding in several languages.

Experiences of symptom burden among young children born with esophageal atresia-tracheoesophageal fistula: a US focus group study.

Background: Children born with esophageal atresia-tracheoesophageal fistula (EA-TEF) can suffer from aerodigestive morbidity that impairs their quality of life and can persist into adulthood. Ameliorating their symptom burden requires a thorough understanding of the symptom experiences that children have early in life. We aimed to explore parents' experiences of their children's aerodigestive symptom burden during the first years of life after being born with EA-TEF.

Minimally invasive Rives-Stoppa (MIRS) technique: a technique of retromuscular repair of ventral hernias preserving the posterior rectus sheath.

Purpose: Retromuscular techniques of ventral hernia (VH) repair involve division of the posterior rectus sheath, entailing a risk of suture line disruption when the gap is sutured or of abdominal swelling when it is not, or when any type of posterior releasing incision is performed. To prevent these drawbacks, we describe a technique of retromuscular repair preserving the posterior sheath integrity.

Methods: The technique involved periumbilical skin incision, hernia reduction, suture of the orifice, bilateral incision of the anterior rectus sheath close to the midline, approximating the medial borders of these aponeurotic incisions by suture, retrorectus mesh deployment and approximation by suture of both lateral borders of the aponeurotic incisions over the mesh, thanks to anterior releasing incisions.