Publications by authors named "P David Cooper"

Under Ir-catalyzed conditions, N-2°-alkyl or N-3°-alkyl substituents of diverse tertiary aryl amides can be exchanged with the ortho-aryl C─H bond of the aromatic unit. These alkyl transfer processes employ a homochiral diphosphonite ligand, and this enforces notable levels of enantioconvergency for non-stereodefined 2°-alkyl substituents. Related processes allow the intermolecular transfer of N-2°-alkyl substituents, providing a convenient means of introducing difficult-to-install ortho-alkyl units.

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Background: The bone marrow microenvironment, comprising various cell types and molecular signals, finely orchestrates the self-renewal and lineage commitment of hematopoietic stem cells (HSCs). Although most investigations have centered on mesenchymal stem cells (MSCs) from long bones, the distinct properties and immunoregulatory functions of craniofacial bone marrow derived MSCs remain largely unexplored. Notably, jawbone MSCs not only exhibit a robust capacity for promoting hematopoietic regeneration but also offer therapeutic potential in infectious diseases.

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