Principles, barriers and enablers to agroecological animal production systems: a qualitative approach based on five case studies.

Agroecology is among the most promising options to alleviate the negative impacts of animal farming on the environment and build local food systems based on ethically acceptable production methods. So far, most of the research on agroecological animal production systems was conducted at farm scale, and the potential of agroecological principles addressing social dimensions and food system-level approaches has been underexplored. Here, we analyse how the whole set of agroecological principles was mobilised in five case studies on grassland-based, silvopastoral or integrated crop-livestock systems in Switzerland, Guadeloupe, French uplands, Bulgaria and Andalucía.

Neutrophil extracellular trap formation and gene programs distinguish TST/IGRA sensitization outcomes among Mycobacterium tuberculosis exposed persons living with HIV.

Persons living with HIV (PLWH) have an increased risk for tuberculosis (TB). After prolonged and repeated exposure, some PLWH never develop TB and show no evidence of immune sensitization to Mycobacterium tuberculosis (Mtb) as defined by persistently negative tuberculin skin tests (TST) and interferon gamma release assays (IGRA). This group has been identified and defined as HIV+ persistently TB, tuberculin and IGRA negative (HITTIN).

Identification of new ETV6 modulators through a high-throughput functional screening.

transcriptional activity is critical for proper blood cell development in the bone marrow. Despite the accumulating body of evidence linking malfunction to hematological malignancies, its regulatory network remains unclear. To uncover genes that modulate repressive transcriptional activity, we performed a specifically designed, unbiased genome-wide shRNA screen in pre-B acute lymphoblastic leukemia cells.

Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis.

Persons living with HIV (PLWH) are at increased risk of tuberculosis (TB). HIV-associated TB is often the result of recent infection with Mycobacterium tuberculosis (M. tuberculosis) followed by rapid progression to disease.