Exceptional Response to Immunotherapy-based Treatment in Compound -Mutated Oligometastatic Pulmonary Sarcomatoid Carcinoma: A Case Report.

Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive subtype of non-small cell lung cancer (NSCLC) with limited treatment options and poor prognosis. mutations generally respond to tyrosine kinase inhibitors (TKIs)-based targeted therapy but are typically associated with resistance to immunotherapy. We report a case of oligometastatic PSC harboring compound mutations (p.

Complete Blood Count (CBC) Parameters as a Cost-Effective Tool for Early Diagnosis of Pediatric Sepsis: A Retrospective Cross-Sectional Study.

Introduction: Early recognition of pediatric sepsis is crucial for timely intervention, prevention of mortality, and improving long-term outcomes in children. However, the lack of advanced diagnostics in resource-limited settings poses a significant challenge to early diagnosis and intervention. Complete blood count (CBC) parameters are routinely performed, cost-effective, and readily available, yet their diagnostic utility in pediatric sepsis remains underutilized.

Brain network signatures of spatial memory in adolescents at risk for substance use.

Background: Examining youth before engagement in risky behaviors may help identify neurobiological signatures that prospectively predict susceptibility to initiating and escalating alcohol and other substance use. Given that frontal and medial temporal (e.g.

Contamination profile and potential human health risks of radon in groundwater of southwest region of Punjab, India.

Radon (Rn) is a naturally occurring radioactive gas produced by the decay of uranium-bearing minerals in rocks and soils. Long-term exposure to elevated radon levels in drinking water is associated with an increased risk of stomach and lung cancers. This study aims to assess the concentration of radon in groundwater and evaluate its potential health risks in six cancer-affected districts, i.