Genomic surveillance in Morocco tracks SARS-CoV-2 variant shift from Alpha to Omicron sublineage JN1.

The persistent evolution of SARS-CoV-2 highlights the crucial role of genomic surveillance in tracking emerging variants and guiding public health interventions. We performed whole-genome sequencing on 235 SARS-CoV-2-positive samples collected across Morocco between 2021 and 2024 to characterize viral evolution and variant dynamics. Our analysis revealed a temporal shift in variant prevalence that paralleled global trends: initial co-circulation of Alpha and Delta variants, followed by complete replacement by Omicron and its sub-lineages in 2022.

Association of TNFRSF13B Gene Polymorphisms With SARS-CoV-2 Infection, Severity, and Humoral Immune Response in a Moroccan Population.

Background And Aims: Genetic factors, including polymorphisms in the TNFRSF13B gene, which regulates humoral immunity, can influence susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aims to investigate the association between two polymorphisms, rs12603708 and rs3751987, and SARS-CoV-2 susceptibility, disease severity, and humoral immune responses in a Moroccan population.

Materials And Methods: A total of 303 unvaccinated COVID-19 patients (151 severe cases and 152 asymptomatic/moderate cases) and 150 individuals from a SARS-CoV-2-negative group were included in the analysis.