Molecular engineering of 3-arylated tetrazo[1,2-]indazoles: divergent synthesis and structure-property relationships.

The synthetic scope of 3-arylated tetrazo[1,2-]indazoles is reported based on a Pd-catalyzed Liebeskind-Srogl cross-coupling reaction followed by an N-cyclisation process. The reactivity of the nitrogen atoms was used to further diversify these N-rich polyaromatic tetrazo[1,2-]indazoles in a panel of reactions (protonation, selective oxidation, metallations). Selective -C-H activation/functionalization on the heterocycle was also demonstrated with three transition metals (TM = Pd, Ir and Rh).

Bisphenol a (BPA) aggravate the adverse effect on physiological and biochemical response in freshwater mussel .

Bisphenol A (BPA) is a chemical compound extensively employed in plastic manufacturing, and this pollutant has been detected in diverse aquatic organisms, notably bivalves. In order to comprehend the ecological and toxicological consequences of BPA Bisphenol A in these organisms, it is essential to examine the physiological and biochemical effects and identify areas where our understanding is lacking. This knowledge is crucial for determining the environn ental threat posed by bisphenol A and assisting decision-makers in establishing the appropriate priorities.

Alkali halides as nucleophilic reagent sources for N-directed palladium-catalysed -C-H halogenation of -tetrazines and other heteroaromatics.

A general palladium-catalysed selective C-H halogenation reaction is reported, which was successfully achieved for a large variety of functionalized aromatic rings incorporating diverse N-directing groups. By using simple alkali halides of MX type as the nucleophilic reagent source (M = Li, Na, K, Cs and X = I, Br and Cl), and phenyliodanediacetate oxidant, clean C-H-iodination, bromination and chlorination reactions were performed. This general protocol of selective -monohalogenation, which complements but contrasts with the classical methods using electrophilic reagents, is achievable in a short time (30 min) with microwave irradiation assistance.

Solvent-free ruthenium-catalysed triflate coupling as a convenient method for selective azole-o-C-H monoarylation.

Metal-catalysed ortho-directed C-H functionalization usually faces selectivity issues in the competition between mono- and disubstitution processes. We report herein the ruthenium-catalysed N-directed C-H monoarylation of arylpyrazoles with a selectivity of up to 96% or that generally reaches values above 80%. This selectivity is an effect of solvent-free conditions associated with sulfonate reagents, in the absence of frequently used acidic additives.