Chronic non-healing ulcer reveals pyoderma gangrenosum: A case report.

Pyoderma gangrenosum is a rare, ulcerative skin condition with complex diagnostic and therapeutic challenges, particularly in cases without associated systemic conditions. We present the case of a 71-year-old female with a chronic, non-healing ulcer, initially unresponsive to conventional topical treatments. After a thorough evaluation and biopsy, a diagnosis of pyoderma gangrenosum was made.

Progressive Soft Tissue Swelling in a Pediatric Patient Leading to the Diagnosis of Fibrodysplasia Ossificans Progressiva: A Case Report.

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by progressive heterotopic ossification (HO) and congenital malformation of the great toes. This case describes a 5-year-old Caucasian girl who initially presented with painless neck and back swelling as well as severe limitation of movement in the neck and shoulder girdle, who was diagnosed as FOP following tissue-based genetic testing revealing the ACVR1 (p.Arg206His) pathogenic variant.

Topical delgocitinib for the treatment of chronic hand eczema.

Purpose: Chronic hand eczema (CHE) is a prevalent dermatological condition characterized by significant morbidity and impaired quality of life. Delgocitinib, a pan-JAK inhibitor, has emerged as a promising topical treatment for CHE, targeting key cytokine-mediated inflammatory pathways involved in the disease. Delgocitinib 20 mg/g (2%) cream was approved by the European Medicines Agency (EMA) in 2024 for moderate-to-severe CHE, and its U.

Low-dose isotretinoin for the treatment of Morbihan's disease in a 69-year-old Asian male: A case report.

Morbihan's disease is a rare form of facial lymphedema often associated with chronic rosacea and other skin diseases such as acne. It presents as indurated erythematous plaques in the upper face, which can be challenging to treat. We report a 69-year-old male of Asian background with a 4-year history of facial swelling and redness, unresponsive to prior treatments.

Oral roflumilast for psoriasis: a real-world 24-week prospective cohort study.

Objective: Psoriasis is a chronic inflammatory skin disease with significant physical and psychological burden, often associated with comorbidities such as obesity and cardiovascular disease. Current treatments include conventional systemic therapies and targeted biologic and non-biologic therapies, with several limitations related to safety, efficacy, and cost. Roflumilast, a selective PDE4 inhibitor, shows potential as an oral therapy for psoriasis due to its anti-inflammatory effects and favorable safety profile.

A Narrative Review of the OX40-OX40L Pathway as a Potential Therapeutic Target in Atopic Dermatitis: Focus on Rocatinlimab and Amlitelimab.

Atopic dermatitis (AD) is a common chronic inflammatory skin disease involving complex immune dysregulation, including the OX40-OX40L pathway. Rocatinlimab and amlitelimab, monoclonal antibodies targeting OX40 and OX40L, respectively, have shown promise in treating moderate-to-severe AD. Both therapies have demonstrated significant efficacy in reducing disease severity, with favorable safety profiles and no serious treatment-related adverse events.

Interpersonal sensitivity and response to selective serotonin reuptake inhibitors in patients with acute major depressive disorder.

Background: Patients with major depression often suffer from excessive interpersonal sensitivity, although it is not typically measured in antidepressant clinical trials. Preliminary evidence suggests selective serotonin reuptake inhibitors have the capacity to reduce interpersonal sensitivity.

Methods: This was a pooled analysis of data from 1709 patients in three randomized, double-blind, placebo-controlled trials of fluoxetine and paroxetine for acute major depressive disorder.

A Theranostic Approach to Imaging and Treating Melanoma with Pb/Pb-Labeled Antibody Targeting Melanin.

Metastatic melanoma is a deadly disease that claims thousands of lives each year despite the introduction of several immunotherapeutic agents into the clinic over the past decade, inspiring the development of novel therapeutics and the exploration of combination therapies. Our investigations target melanin pigment with melanin-specific radiolabeled antibodies as a strategy to treat metastatic melanoma. In this study, a theranostic approach was applied by first labeling a chimeric antibody targeting melanin, c8C3, with the SPECT radionuclide Pb for microSPECT/CT imaging of C57Bl6 mice bearing B16-F10 melanoma tumors.

Investigation of the Relationships between Coat Colour, Sex, and Morphological Characteristics in Donkeys Using Data Mining Algorithms.

This study was carried out in order to determine the morphological characteristics, body coat colour distribution, and body dimensions of donkeys raised in Turkey, as well as to determine the relationships between these factors. For this reason, the predictive performance of various machine learning algorithms (i.e.

Chronic Noise Affects Middle Ear Resonance and Absorbance in Industrial Workers.

Background: The effect of chronic noise on the middle ear is not fully known. This study aimed to evaluate the middle ear functions of metal workers exposed to chronic noise using wideband tympanometry.

Methods: In this study, 62 male workers exposed to chronic noise and 30 healthy men were included.