Molecular differences in the nasal microenvironment of chronic rhinosinusitis with nasal polyposis: a systematic review.

Objectives: The present review aims at an insight into the pathophysiology of chronic rhinosinusitis with nasal polyposis through the combination of three tissue sources: (1) nasal polyp, (2) neighboring non-polypoid mucosa (MS) and (3) healthy controls.

Methods: The primary outcomes included three lists of molecules (1) those significantly different between nasal polyp, neighboring non-polypoid mucosa and controls (2) those up/downregulated in nasal polyp, but comparable between MS and controls and (3) those comparable between nasal polyp and neighboring non-polypoid mucosa, but different between NP and controls.

Results: Ten studies investigating a large variety of 68 molecules presented comparisons between nasal polyp and neighboring non-polypoid mucosa in endotype-specified populations.

Association Between Vitamin D Deficiency and Papillary Thyroid Cancer: Tertiary Center Experience.

Papillary thyroid carcinoma is the most common thyroid malignancy, with a higher incidence in women. Vitamin D deficiency has been proposed as a potential risk factor for various cancers, including thyroid cancer. This study investigates the association between vitamin D deficiency and papillary thyroid carcinoma.

Surgical outcomes of primary carcinosarcoma of the gallbladder after curative resection: A rare case series.

Introduction: Primary carcinosarcoma is a rare neoplasm of the gallbladder, and is characterized by collision elements of the adenocarcinomatous and sarcomatous components. The tumours comprise both malignant epithelial and mesenchymal elements, and are usually very aggressive, conferring poor prognosis. Adenocarcinomas are the most common neoplasms of the gall bladder, while carcinosarcoma are extremely rare, with a global prevalence rate of less than 1%.