Antifungal Activity of Thymus vulgaris L. Essential Oil Against Candida Species Causing Otomycosis: Anti-Virulence Activity, Synergistic Potential, and Cell Wall Effect.

Otomycosis is a fungal infection of the external auditory canal, predominantly caused by Candida spp. The increasing resistance of these pathogens to conventional antifungal agents requires the exploration of alternative therapeutic approaches. This study was designed to assess the antifungal, anti-virulence, synergistic potential, and mechanism of action of Thymus vulgaris essential oil (EO) against Candida spp.

Clinical Presentations, Cluster Analysis and Laboratory-Based Investigation of Otomycosis-A Single Center Experience.

Species of () complex and complex are predominant molds that are causative agents of otomycoses. The goal of this study was to investigate the clinical presentation, diagnostic procedure, and appearance of relapse in patients with -otomycosis, as well as to determine the biofilm production ability of species isolated in relapse. Thirty patients with laboratory evidenced -otomycosis followed by two check-ups (30 and 60 days after initiation of treatment with antimycotics for local application) were included in the study.