Publications by authors named "Nitin A John"

Background: Language is one of the most fundamental aspects of any society. It is how individuals communicate with one another, form relationships and foster a feeling of community. Language processing is one of the most common, yet complex, tasks we perform regularly.

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Background: Hypothyroidism is a common endocrine disorder, which adversely affects the developing central nervous system in the pediatric population. Despite treatment, patients may continue to experience neurological impairments such as cognitive dysfunction. P300 is an event-related potential (ERP) which is often considered as a marker for cognition.

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Background: Poor sleep quality is observed in patients of hypothyroidism. The patient complains of sleeplessness, excessive day-time sleepiness, snoring, arousals and breathlessness. The decrease in quantity and quality of sleep occurs in various degrees of severity in patients of hypothyroidism.

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COVID-19 caused by the novel coronavirus SARS-CoV-2 has resulted in significant morbidity and mortality worldwide. Long term respiratory complications secondary to COVID-19 have been described, which were not fully explored. The severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) directly infects endothelial cells, with inducing marked endothelial damage and inflammation contributing to increased arterial stiffness.

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The capability of the human brain to redeploy in accordance to the activities and experiences is deemed as neuroplasticity. As a result, neuroplasticity can be visualized as a required adaptation to all brain processes. Broadly classified into structural, functional, biochemical and behavioural neuroplasticity, structural neuroplasticity includes neurogenesis and synaptogenesis.

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During routine heart rate variability recording in an elderly male, bi-peaked R waves were recorded consistently. Initially, it was thought to be because of technical issues, which were ruled out systematically; next, it was believed to have been caused by cardiac pathology, which was evaluated using ECG and echocardiography.

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Introduction: Globally, 466 million (5%) are having hearing disability of which 34 million are children. In India, 63 million people (6.3%) suffer from significant auditory loss.

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Background: Research evidence suggests the role of the vestibular system in cognitive functions like visuospatial memory, objective memory, spatial navigation, etc. Vestibular cortices send projection to the hippocampus and to the medial entorhinal cortex (MEC); the latter houses place cells, grid cells, and head direction cells, which play a major role in the formation of a cognitive map based on inputs from the vestibular apparatus. So, the present study aimed to assess cognitive functions in vestibular disorder patients.

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Background: Thermal threshold testing (TTT) is a simple non-invasive approach for diagnosing diabetic neuropathy earlier. Conventionally the TTT is done in all four limbs and at least 6 trials are done to obtain the mean threshold, which is time consuming.

Aim: We propose to assess the validity and reliability of reduced number of trials of TTT in the lower limbs.

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Background: Cardiovascular diseases (CVD) account for approximately one-third of all deaths worldwide. The incidence of cardiovascular events such as myocardial infraction has been reported to be progressively increasing with age, especially with existing comorbidities such as hypertension, diabetes and obesity. Assessing arterial stiffness indices may serve as a screening tool in identification of population at risk of cardiovascular diseases and assist in implementation of preventive measures and early treatment in this population.

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Background: Diabetes mellitus (DM) is associated with increased risk of morbidity and premature mortality due to its various complications. In an Indian study, the prevalence of diabetic peripheral neuropathy (DPN) in type 2 diabetic subjects was shown to be 29.2%.

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Background: Smartphones have become an indispensable part of almost everyone's life. India has now become the leading and second-largest Smartphone market in the world. It has been noted that the purpose of Smartphone usage has exceptionally changed over the past few years, especially among students, professionals, and the common man.

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The emergence of the SARS-CoV-2 Omicron variant, classified as a Variant of Concern (VoC) in November 2021, marked a significant shift in the COVID-19 landscape. This study investigates the subsequent development of a novel Omicron sublineage, JN.1, which displays distinctive mutations in the spike protein.

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Introduction: Diagnosing diabetic neuropathy is a challenge at times as it is asymptomatic. Diagnosing diabetic neuropathy involves the use of quantitative sensory testing, nerve conduction study, and autonomic testing. Tempearture threshold testing (TTT) can aid in diagnosing small fiber neuropathy at early stages.

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Background: The increasing elderly population makes frailty an increasing concern in society with vulnerability to stress and functional decline. Unrecognised comorbidities are common among the elderly due to lack of mention by the patients. Physicians should be equipped with effective interviewing skills along with the use of screening tools to assess any impairments in activities of daily living, cognition and signs of depression.

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Coronavirus disease 2019 (COVID-19) is caused due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Both immediate and long-term adverse effects arise out of this disease's aftermath. It involves various organs, which include endocrine glands, nervous system, musculoskeletal system, and other organs.

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Cardiovascular diseases account for one-third of deaths worldwide. Arterial stiffness is considered as useful predictor of cardiovascular events as measured by pulse wave velocity. Hypertension promotes collagen production causing increase in vascular thickness and arterial stiffness.

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Introduction: Anxiety and stress are challenging conditions that result in perturbation of the body's homeostasis. It disturbs one's physical and mental state of equilibrium. There are many ways to overcome anxiety and stress, however, the best among many remedies is yoganidra, as it achieves optimum functioning of not only our body but also our mind.

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Introduction: Modernization has led to greater usage of Air Conditioners (ACs) in our daily lives. It is observed that the occupants of office buildings with ACs consistently report on average more symptoms than do occupants of office buildings with natural ventilation referred to as Sick Building Syndrome (SBS). The appearance of symptoms reduces work efficiency and increases absenteeism due to sickness (sickness absenteeism).

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Globally, we are seeing a rise in non-communicable diseases such as obesity, hypertension, diabetes, metabolic syndrome, chronic respiratory diseases, cancer, etc., due to stressful lifestyle in this competitive world. Most of the non-communicable diseases are associated with lifestyle behavior.

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Objectives: Metabolic syndrome (MS) is a collection of metabolic disorders including hyperglycemia, hypertension and dyslipidemia. The outcome of metabolic syndrome depends on structural changes in heart like increased left atrial size or increased left ventricular mass. This study was done to determine the echocardiography abnormalities in metabolic syndrome.

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Background: Cytological smear and cell block are commonly used to diagnose pleural fluid effusion. However, there is a paucity of information in the literature where a comparison between a cytological smear and a cell block with corresponding pleural biopsy has been done. This study aimed to evaluate the accuracy of cytological smears, cell blocks, and pleural biopsy for the diagnosis of malignant tumors.

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Background: Viewing of visual imagery of forest or nature is known for producing physiological and psychological relaxation of mind and body. Nature surroundings are colourful and vary from green of plants, blue of water and red, orange, yellow and violet of flowers. These coloured imageries also known to affect our emotion; may lead to joy, sorrow, happiness grief etc.

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COVID-19 emerged in Wuhan, China, but was caused by the original coronavirus, severe acute respiratory syndrome associated coronavirus-2 (SARS-CoV2). In early 2020, there was a widespread breakout of cases well over world, resulting in an epidemic that rapidly escalated to become a pandemic. This abruptly shook the global healthcare system.

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