Publications by authors named "Nitesh Kumar Gupta"
Oxidative stress-induced mitochondrial dysfunction is implicated in the pathogenesis of Parkinson's disease (PD). In a previous study, we reported that an extract of T. cordifolia (TCE) possessed antioxidant and anti-apoptotic properties that improved mitochondrial function against rotenone-induced neurotoxicity.
View Article and Find Full Text PDFHAT and HDAC: Enzyme with Contradictory Action in Neurodegenerative Diseases.
Mol Neurobiol
November 2024
Article Synopsis
- Epigenetics, particularly histone modifications like acetylation, plays a crucial role in understanding and treating neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s.
- Imbalances in enzymes like histone acetyltransferases (HATs) and histone deacetylases (HDACs) can negatively affect gene expression and neurophysiological functions.
- Recent therapeutic approaches focus on HDAC inhibitors that enhance acetylation levels, aiming to improve memory formation and neuronal plasticity, although concerns about their target specificity remain.