Publications by authors named "Nirupa D Jayaraj"
Keratinocyte-derived extracellular vesicles in painful diabetic neuropathy.
Neurobiol Pain
December 2024
Painful diabetic neuropathy (PDN) is a challenging complication of diabetes with patients experiencing a painful and burning sensation in their extremities. Existing treatments provide limited relief without addressing the underlying mechanisms of the disease. PDN involves the gradual degeneration of nerve fibers in the skin.
View Article and Find Full Text PDFPainful diabetic neuropathy (PDN) is a challenging complication of diabetes with patients experiencing a painful and burning sensation in their extremities. Existing treatments provide limited relief without addressing the underlying mechanisms of the disease. PDN involves the gradual degeneration of nerve fibers in the skin.
View Article and Find Full Text PDFArticle Synopsis
- - Painful diabetic neuropathy (PDN) is a common and challenging complication of diabetes, marked by nerve pain linked to changes in nerve cell activity and damage.
- - Research using single-cell RNA sequencing in a mouse model shows that the Mas-related G protein-coupled receptor d (Mrgprd) is overexpressed in certain pain-related nerve cells in PDN, and blocking its signaling alleviates pain symptoms.
- - The study suggests that targeting Mrgprd could lead to new and effective treatments for neuropathic pain in PDN, addressing a significant gap in current therapeutic options.
Misregulation of mitochondria-lysosome contact dynamics in Charcot-Marie-Tooth Type 2B disease Rab7 mutant sensory peripheral neurons.
Proc Natl Acad Sci U S A
October 2023
Inter-organelle contact sites between mitochondria and lysosomes mediate the crosstalk and bidirectional regulation of their dynamics in health and disease. However, mitochondria-lysosome contact sites and their misregulation have not been investigated in peripheral sensory neurons. Charcot-Marie-Tooth type 2B disease is an autosomal dominant axonal neuropathy affecting peripheral sensory neurons caused by mutations in the GTPase Rab7.
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- Painful diabetic neuropathy (PDN) affects 25% of diabetics, causing neuropathic pain linked to calcium overload and neurological degeneration in dorsal root ganglion (DRG) neurons.
- Research shows that elevated mitochondrial fission proteins in DRG neurons lead to fragmented mitochondria and increased calcium signaling due to a high-fat diet in mouse models.
- Targeting the mitochondrial calcium uniporter may restore normal mitochondrial function, reduce nerve damage, and alleviate pain, suggesting a potential therapeutic approach for PDN and other similar neurodegenerative diseases.
Painful diabetic neuropathy (PDN) is an intractable complication of diabetes that affects 25% of patients. PDN is characterized by neuropathic pain and small-fiber degeneration, accompanied by dorsal root ganglion (DRG) nociceptor hyperexcitability and loss of their axons within the skin. The molecular mechanisms underlying DRG nociceptor hyperexcitability and small-fiber degeneration in PDN are unknown.
View Article and Find Full Text PDFBackground: Small fiber neuropathy is a well-recognized complication of type 2 diabetes and has been shown to be responsible for both neuropathic pain and impaired wound healing. In previous studies, we have demonstrated that ganglioside GM3 depletion by knockdown of GM3 synthase fully reverses impaired wound healing in diabetic mice. However, the role of GM3 in neuropathic pain and small fiber neuropathy in diabetes is unknown.
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