Sexually dimorphic associations between Vitamin D metabolites, blood pressure, and placental inflammatory markers in Normoevolutive, preeclamptic and obese pregnancies.

Objectives: Calcitriol, the active vitamin D (VD) metabolite, abates inflammation and reduces blood pressure (BP). In the human placenta, calcidiol bioconversion into calcitriol is sexually dimorphic, resulting in differential VD-dependent effects. During pregnancy, obesity (OB) and preeclampsia (PE) have been linked to inflammation, hypertension, and impaired VD metabolism.

Polycystic ovary syndrome with feasible equivalence to overweight as a risk factor for non-alcoholic fatty liver disease development and severity in Mexican population.

Introduction And Objectives: Polycystic ovary syndrome (PCOS) is the most common endocrinology disorder in women of reproductive age; these patients have a higher risk of suffering from non-alcoholic fatty liver disease (NAFLD). We determine the frequency of NAFLD in Mexican patients with PCOS and matched-controls.

Patients And Methods: Cross-sectional study, with 98 women of 18-44 years old.

The diagnostic and initial approach of the patient with non-alcoholic fatty liver disease: role of the primary care provider.

Non-alcoholic fatty liver disease (NAFLD) represents a broad spectrum of liver damage, ranging from simple steatosis to steatohepatitis and fibrosis; as well, there is a close association between NAFLD, obesity, metabolic syndrome and type 2 diabetes mellitus. There is a certain degree of uncertainty regarding the natural history and prognosis of NAFLD; however, several methods are currently used for its diagnostic approach. In the first instance, non-invasive tests could be used to identify patients at low risk of developing fibrosis and to establish more easily the need for a liver biopsy, whose accuracy in the evaluation of fibrosis has been questioned, mainly due to errors of intra and interobserver sampling, technical problems and cost, which limits its use.

Understanding the association of polycystic ovary syndrome and non-alcoholic fatty liver disease.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-age women. Patients with non-alcoholic fatty liver disease (NAFLD) often suffer from metabolic syndrome, atherosclerosis, ischemic heart disease, and extrahepatic tumors, conferring a lower survival than the general population; therefore it is crucial to study the association between NAFLD and PCOS since it remains poorly understood. Insulin resistance (IR) plays a central role in the pathogenesis of NAFLD and PCOS; also, hyperandrogenism enhances IR in these patients.