Thirty-Day And One-Year Outcomes Of Navitor Transcatheter Aortic Valve In Low- or Intermediate-Risk Patients.

Background: The Navitor transcatheter aortic valve is a self-expanding, intra-annular valve indicated for patients with severe aortic stenosis (AS) at high or extreme surgical risk.

Objectives: To assess the safety and effectiveness of the Navitor valve in severe AS patients at low or intermediate surgical risk.

Methods: VANTAGE is a prospective, single-arm, multicenter study.

Transcatheter Aortic Valve Replacement With Balloon- Versus Self-Expandable Bioprostheses for the Treatment of Bicuspid Aortic Valve Stenosis.

Background: Differences between balloon- and self-expandable transcatheter heart valves (BE-THVs and SE-THVs, respectively) may influence the outcomes of transcatheter aortic valve replacement for bicuspid aortic valve (BAV) stenosis.

Methods: Consecutive patients undergoing transcatheter aortic valve replacement with BE-THV or SE-THV for computed tomography-diagnosed bicuspid aortic valve stenosis at 29 centers were included. The primary outcome was death or stroke.

Transcatheter mitral repair in patients with symptomatic moderate functional mitral regurgitation: 1-year outcomes from the MiCLASP study.

Background: Current clinical guidelines do not recommend mitral transcatheter edge-to-edge repair (M-TEER) for patients with moderate functional mitral regurgitation (FMR), and the implications of M-TEER in this population are not well documented.

Aims: We aimed to assess M-TEER outcomes in patients with symptomatic moderate FMR compared to those with FMR ≥3+ who were treated with the PASCAL system in the MiCLASP study.

Methods: Patients were stratified by baseline FMR grade (2+ or ≥3+).

The Impact of THV Platforms on Transfemoral TAVR in Complex Vascular Access: Insights From the Hostile Registry.

Background: The choice of transcatheter heart valve (THV) platform, including self-expanding valves (SEVs) and balloon-expandable valves (BEVs), may influence outcomes in patients with peripheral artery disease (PAD) undergoing transfemoral transcatheter aortic valve replacement (TAVR). This relationship remains underexplored in high-risk populations with challenging vascular access.

Aims: This study assessed the impact of SEVs and BEVs on clinical outcomes in PAD patients, considering hostile score severity.

Multiphase aortic valve calcium scoring on true-non-contrast and calcium-preserving spectral reconstructions using dual-source photon-counting detector CT.

Objectives: This study investigated differences between aortic valve calcium (AVC) scores derived from true non-contrast (TNC) and virtual-non-contrast reconstructions acquired with photon-counting detector CT (PCD-CT) and the impact of ECG-phase variability on AVC scores.

Materials And Methods: A hundred patients undergoing PCD-CT for transcatheter aortic valve implantation (TAVI) planning were retrospectively analyzed. Scores were computed using the Agatston methodology for TNC and virtual-non-iodine (VNI) reconstruction at scanner-selected optimal phase (best) and a fixed ECG-phase (300 ms).

Single versus Dual Antiplatelet Therapy in Patients with Severe Peripheral Arterial Disease Undergoing TAVI: Insights from The Hostile Registry.

Aims: Single antiplatelet therapy (SAPT) has been shown to be a safer alternative to dual antiplatelet therapy (DAPT) in patients without atrial fibrillation undergoing transcatheter aortic valve implantation (TAVI). However, antithrombotic therapy for TAVI patients with severe peripheral artery disease (PAD) remains an underexplored area. This study aimed to evaluate and compare the outcomes of SAPT and DAPT in this high-risk patient population.

Association between post-PCI vessel fractional flow reserve (vFFR) and optical coherence tomography (OCT) findings: Results from the FAST OCT study.

Aims: Reduced post-PCI fractional flow reserve (FFR) and suboptimal optical coherence tomography (OCT) findings are associated with impaired outcomes. Angiography-derived vessel FFR (vFFR) has emerged as an accurate alternative to pressure-wire based FFR. This study sought to define the association between post-PCI vFFR and OCT findings.

Long-Term Durability of Transcatheter Aortic Valves in Patients With Bicuspid Aortic Stenosis.

Background: Data concerning the long-term durability of transcatheter aortic valves (TAVs) in patients with bicuspid aortic stenosis (AS) are lacking.

Aims: The study aims to report data on long-term valve durability following transcatheter aortic valve replacement (TAVR) in bicuspid AS.

Methods: This multicentre registry included patients who underwent TAVR for bicuspid AS with at least 2-year echocardiographic follow-up.

Stent Frame Deformation of Self-Expanding Transcatheter Heart Valves in Bicuspid Aortic Stenosis and Impact on Valve Performance.

Aims: To evaluate stent frame expansion and ellipticity of the Evolut™ transcatheter heart valve (THV) and its subsequent impact on valve performance in patients with bicuspid aortic stenosis (AS) using pre- and post-procedural cardiac computed tomography (CT). In transcatheter aortic valve implantation (TAVI) for native bicuspid AS, concerns arise regarding the risk for reduced stent frame expansion and increased ellipticity compared with valves implanted in tricuspid AS. The implications of stent frame under-expansion and eccentricity on THV performance remain unclear.

How accurate is intraprocedural transthoracic echocardiography in assessing aortic regurgitation after transcathether aortic valve implantation? A single center experience.

Aim Transthoracic echocardiography (TTE) has been commonly used to assess the aortic regurgitation (AR), particularly paravalvular leakage, during transcatheter aortic valve implantation (TAVI). We sought to investigate the accuracy of intraprocedural TTE to grade the AR severity by comparing with discharge TTE assessments. Methods Consecutive patients received balloon expandable (BE) or self-expanding (SE) transcatheter heart valves with both intraprocedural TTE and discharge TTE AR assessments were included.

Immediate versus staged complete revascularization in patients presenting with multivessel disease and ST- or non-ST-segment elevation acute coronary syndrome.

Background: Recent randomized trials have suggested that immediate complete revascularization (ICR) is a viable alternative to staged complete revascularization (SCR) in patients with acute coronary syndrome (ACS) and multivessel disease. However, long-term outcomes comparing ICR with SCR in ST-segment elevation (STE) and non-ST-segment elevation (NSTE) ACS remain unclear.

Methods: This study analyzes 2-year follow-up data from the BIOVASC trial, randomizing ACS patients to ICR or SCR.

Transcatheter Aortic Valve Replacement for Patients With Moderate Aortic Stenos is-A Propensity Matched Analysis.

Moderate aortic stenosis (AS) has been linked to impaired long-term survival. Whether transcatheter aortic valve replacement (TAVR) may improve clinical outcome of moderate AS is unknown. We aimed to investigate the potential clinical benefits of TAVR for patients with moderate AS irrespective of LVEF.

Heart failure: assessment of the global economic burden.

Background And Aims: Heart failure (HF) is a major public health issue, imposing substantial costs on healthcare systems and societies. This study aimed to provide a contemporary overview of its global economic impact.

Methods: A systematic search of four databases was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Coronary Stent Imaging with Photon-counting Detector CT.

Photon-counting detector (PCD) CT offers promising advancements in stent imaging over traditional CT by providing enhanced spatial resolution and spectral capabilities. This article aims to provide an overview of the current literature on coronary stent imaging using PCD CT technology. The high spatial resolution of PCD CT effectively reduces stent blooming artifacts and enhances in-stent visibility and restenosis assessment.

Percutaneous Coronary Intervention for Left Main Disease in High Bleeding Risk: Outcomes from a Subanalysis of the Delta 2 Registry.

High bleeding risk (HBR) is a challenge in patients with complex coronary lesions undergoing percutaneous coronary intervention (PCI). This study investigates HBR in a wide and comprehensive cohort of patients undergoing left main (LM) PCI and reports in-hospital and follow-up outcomes. The analysis was performed on data from the DELTA (Drug Eluting Stent for Left Main Coronary Artery) 2 Registry, which included patients who underwent LM PCI at 19 centres worldwide.

REdo transcatheter aortic VALVE implantation for the management of transcatheter aortic valve failure: Design and rationale of the REVALVE study.

Background: The expansion of transcatheter aortic valve implantation (TAVI) into younger and lower risk patients increases the likelihood of future reintervention on the valve due to bioprosthetic valve failure (BVF). However, little is known about the feasibility and outcomes of redo TAVI for BVF.

Methods: REVALVE is an investigator-initiated, open-label, prospective registry, enrolling 300 patients undergoing redo TAVI in approximately 75 centres in 11 countries in Europe and the Middle East.

Prasugrel monotherapy versus standard DAPT in STEMI patients with OCT-guided or angio-guided complete revascularisation: design and rationale of the randomised, multifactorial COMPARE STEMI ONE trial.

Monotherapy with a potent P2Y receptor antagonist after 1 month of dual antiplatelet therapy (DAPT) may reduce bleeding in the absence of increased ischaemic events compared to 12-month DAPT in patients with acute coronary syndrome undergoing percutaneous coronary intervention (PCI). PCI guidance with optical coherence tomography (OCT) may enhance stent expansion. COMPARE STEMI ONE is an international, multicentre, open-label, randomised controlled trial.

Comparing Major Gastrointestinal Bleeding in Patients Receiving Edoxaban Versus Warfarin After Transcatheter Aortic Valve Replacement: Results From the Randomized ENVISAGE-TAVI AF Trial.

Background: Non-vitamin K oral anticoagulants are recommended over vitamin K antagonists in patients with nonvalvular atrial fibrillation (AF). However, the risk of gastrointestinal bleeding may be higher with non-vitamin K oral anticoagulants versus vitamin K antagonists. Patients after successful transcatheter aortic valve replacement (TAVR) who are elderly and frail have worse outcomes with major gastrointestinal bleeding (MGIB), including death.

Evidence of bioprosthetic valve dysfunction during three-year follow-up following TAVR.

Objective: Transcatheter aortic valve replacement (TAVR) has increased significantly in younger patients and patients at lower surgical risk. In this retrospective multicenter study, we aimed to assess for bioprosthetic valve dysfunction (BVD) during three-year follow-up (FU) and potential differences between self-expandable (SEV) and balloon-expandable valves (BEV) under real-world conditions.

Methods: Endpoints were defined according to VARC-3 criteria, including VARC composite endpoints during three-year FU.

The Frontier V Study: Evaluating the Safety and Clinical Performance of a Large-Bore Vascular Closure Device After Femoral Arterial Access.

Background: Vascular complications following large-bore procedures may have a significant impact on patient morbidity and mortality, highlighting the critical need for an effective, safe, and reproducible closure device. We present our prospective multi-center experience with a novel patch-based closure device.

Aim: To evaluate the safety and clinical performance of the PerQseal+ closure system in achieving hemostasis after femoral arterial large-bore access with 14-22 F sheaths.