Development of an All-Hydrocarbon Stapled Peptide Targeting BRK1 in Triple-Negative Breast Cancer.

Wiskott-Aldrich syndrome protein family (WASF) members are key regulators of actin cytoskeleton dynamics at the leading edge of the cell membrane. WASF3 has been demonstrated to directly promote cancer invasion and metastasis in triple-negative breast cancer. WASF3 is incorporated into a heteropentameric protein complex with BRK1, CYFIP1/2, NCKAP1/1L, and ABI1/2/3 termed the WASF Regulatory Complex (WRC) that links upstream signaling pathways to Arp2/3-mediated actin nucleation.

Extensor Hallucis Longus Contracture Following Intramedullary Nailing for a Pilon Fracture.

Extensor hallucis longus (EHL) fibrosis is an uncommon complication following a pilon fracture. This is caused by compartment syndrome from fracture immobilization followed by adhesion of muscle or tendon. Only a few cases of EHL fibrosis secondary to a post-traumatic lower leg fracture have been reported.

Knee Ligament Injuries in the National Football League: Impact of Field Surface Type During the 2020-2023 Seasons.

Introduction A subject of ongoing debate within the National Football League (NFL) community revolves around the comparative risk of anterior cruciate ligament (ACL) injuries on natural versus artificial turf field surfaces. There have been mixed results as to whether there is a difference in injury rates depending on the playing surface and what factors might play a role in affecting these rates. Methods This study aims to compare the incidence of in-game knee ligament tears in the NFL during the 2020-2023 seasons.

Field Surface Type and Season-Ending Lower Extremity Injury in NFL Players.

There is growing concern over the safety of artificial turf when it comes to the incidence of player injuries. The artificial surfaces can withstand more play, are cheaper to maintain, and are more predictable. However, there is concern that this beneficial durability comes at the expense of the forgiveness of the surface, leading to more injuries.