Publications by authors named "Nicholas E-Kai Lim"
Association of Menière's disease with depression and anxiety: a systematic review and meta-analysis.
Eur Arch Otorhinolaryngol
August 2025
Purpose: The persistent and recurring nature of Menière's Disease may pose psychological challenges for patients. The association between Menière's Disease and depression and anxiety remains inconclusive among pre-existing studies. This study seeks to review and synthesise existing evidence regarding the association between Menière's Disease and depression and anxiety.
View Article and Find Full Text PDFBackground: Both anxiety and depression are prevalent among patients with chronic rhinosinusitis (CRS) and associated with poorer outcomes following treatment for CRS. However, the impact of treatment on CRS on mental health remains uncertain. Therefore, this study seeks to evaluate if surgical intervention for CRS may alleviate comorbid depression and anxiety.
View Article and Find Full Text PDFArticle Synopsis
- Motoric cognitive risk syndrome (MCR) is identified by slow walking speed and subjective memory complaints in older adults, and it may serve as an early warning sign for cognitive decline and dementia.
- A systematic review of 20 studies, involving over 1.2 million participants, found that those with MCR had more than double the risk of developing cognitive impairment and dementia compared to those without MCR.
- The findings suggest that MCR could be a valuable predictor of long-term cognitive issues, emphasizing the need for further research to confirm these associations.
Background: Recurrent/Metastatic Nasopharyngeal Carcinoma (RM-NPC) remains difficult to treat and contributes to considerable mortality. The first-line treatment for RM-NPC is Gemcitabine and Cisplatin and second-line treatment options differ. The endemic variant of NPC is associated with Epstein-Barr Virus (EBV).
View Article and Find Full Text PDFObjective: To evaluate the extent to which Benign Paroxysmal Positional Vertigo (BPPV) is associated with a higher prevalence of depression and anxiety in patients.
Data Sources: Three databases including PubMed, Embase, and The Cochrane Library were searched by two independent authors from inception to June 12, 2022 for observational studies and randomized controlled trials investigating the association between BPPV and depression and anxiety. We included studies published as full-length articles in peer-reviewed journals with an adult population aged at least 18 years who have BPPV, detected through validated clinical methods like clinical diagnosis, interview and Dix-Hallpike test.