Publications by authors named "Nicholas A Shoctor"
Introduction: Lupus nephritis (LN) is kidney inflammation that commonly occurs from systemic lupus erythematosus. NF-κB activity is increased in LN patients, leading to elevated circulating concentrations of immune modulators that contribute to LN pathophysiology. This study sought to investigate this phenomenon with the aim of discovering novel serum biomarkers for LN.
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- Neutrophil degranulation contributes to kidney damage in proliferative lupus nephritis (LN), suggesting it plays a role in the illness's progression.
- Measuring specific neutrophil granule proteins in urine could help diagnose and monitor the severity of proliferative LN in patients.
- The study found that urine levels of eight neutrophil granule proteins were significantly higher in patients with active LN compared to healthy individuals, and decreases in these proteins correlated with clinical remission.