Patient Reported Outcomes Pre- and Post-Surgery in Patients With Cleft Lip/Palate: An Assessment of Post-Operative Change Utilizing CLEFT-Q.

ObjectiveTo evaluate how patient-reported outcomes change from pre- to post-operation after common procedures in patients with cleft lip and/or palate (CL/P), as well as compared to patients who did not undergo surgery.DesignRetrospective chart review.SettingTertiary care hospital in the United States.

Demystifying Maxillomandibular Fibrous Dysplasia and its Impact on Dental Development.

Background: Fibrous dysplasia of the jaw (FDJ) is a rare fibro-osseous skeletal disorder that affects the maxilla and/or mandible, often resulting in significant dental complications. However, its impact on dentition and occlusion remains poorly characterized. This study aims to analyze the dental and orthodontic sequelae of FDJ to enhance clinical management and improve patient care.

Occlusal Plane Stability After Curvilinear Mandibular Distraction Osteogenesis.

Curvilinear mandibular distraction osteogenesis (MDO) allows for mandibular lengthening in both the sagittal and vertical planes. However, the stability of these results is less well known. This study examines the stability of the occlusal plane changes in patients who have undergone curvilinear MDO in mixed dentition, with and without orthodontics.

Bilateral Cleft Lip Severity Index in primary cleft rhinoplasty: Correlation with anthropometric outcomes and layperson perception.

Background: The Bilateral Cleft Lip Severity Index (BCLSI) was developed to predict outcomes among patients who underwent bilateral cleft lip (CL) repair. However, its utility among cleft patients undergoing bilateral repair with primary rhinoplasty (PR) has not been studied. Here, we assess whether the BCLSI predicts nasal anthropometric and aesthetic outcomes in patients who had PR at the time of bilateral CL repair.

Ptosis and Craniosynostosis: Revisiting Syndromic and Surgical Associations.

Ocular manifestations, including ptosis, have been associated with certain craniosynostosis syndromes, though the precise relationships with diagnosis and treatment remain unclear. This study examines the prevalence and correlates of ptosis in craniosynostosis. A retrospective cohort study was conducted on all patients with craniosynostosis examined by an ophthalmologist in a tertiary care craniofacial clinic between 2009 and 2024.

Tissue expansion in the pediatric patient: A 23-year single-institution experience.

Background: Given the wide and variable use of tissue expansion in pediatric soft tissue reconstruction, we aimed to characterize its use at our institution over the past 23 years, focusing on clinical outcomes stratified by location, indication, and repeat expansion.

Methods: A multi-surgeon retrospective review of all patients who underwent tissue expander (TE) placement from 2001-2024 was conducted. Demographic, operative, and outcomes data were collected and compared.

CD8 T cells contribute to survival in patients with COVID-19 and hematologic cancer.

Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 patients with cancer who were hospitalized for COVID-19, patients with hematologic cancer had higher mortality relative to patients with solid cancer. In two additional cohorts, flow cytometric and serologic analyses demonstrated that patients with solid cancer and patients without cancer had a similar immune phenotype during acute COVID-19, whereas patients with hematologic cancer had impairment of B cells and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody responses.

CD8 T cells compensate for impaired humoral immunity in COVID-19 patients with hematologic cancer.

Cancer patients have increased morbidity and mortality from Coronavirus Disease 2019 (COVID-19), but the underlying immune mechanisms are unknown. In a cohort of 100 cancer patients hospitalized for COVID-19 at the University of Pennsylvania Health System, we found that patients with hematologic cancers had a significantly higher mortality relative to patients with solid cancers after accounting for confounders including ECOG performance status and active cancer status. We performed flow cytometric and serologic analyses of 106 cancer patients and 113 non-cancer controls from two additional cohorts at Penn and Memorial Sloan Kettering Cancer Center.