Immunomodulatory effects of a short-term gluten-free diet on pediatric celiac disease: findings from a single-cell transcriptomics study.

Celiac disease (CD) is an autoimmune disorder with a strong genetic component, triggered by gluten ingestion. Although a Gluten-Free Diet (GFD) is the standard treatment, its short-term effects on immune cell modulation in pediatric CD remain largely unexplored. This study aimed to investigate transcriptional changes in peripheral blood mononuclear cells (PBMCs) of pediatric CD patients following a strict GFD for 9-10 months, using single-cell RNA sequencing (scRNA-seq).