Publications by authors named "Neilufar Modiri"
Objective: To identify patient factors associated with a clinically significant improvement in semen parameters among infertile men treated with the aromatase inhibitor anastrozole.
Design: Multi-institutional retrospective cohort study.
Setting: Two Tertiary Academic Medical Centers.
Article Synopsis
- The study analyzed the effects of multiple rounds of intralesional collagenase injections (more than the standard 8 injections) on patients with Peyronie disease (PD) between October 2015 and December 2020.
- Out of 330 patients treated, 229 completed at least 8 injections, with varying degrees of clinical improvement observed: 42.8% after 1 round, 38.6% after 2, and 12.5% after 3 rounds.
- The most common side effect recorded was bruising, occurring in over 50% of patients in each round of treatment.
Intralesional collagenase for acute phase Peyronie's disease: a single-center, retrospective cohort study.
Transl Androl Urol
August 2022
Background: Peyronie's disease (PD) can be subdivided into acute and chronic phases. Intralesional collagenase has been shown to improve curvature in the chronic phase. Initial clinical trials excluded patients in the acute phase from treatment.
View Article and Find Full Text PDFTemporal Changes of Clomiphene on Testosterone Levels and Semen Parameters in Subfertile Men.
World J Mens Health
January 2023
Purpose: Clomiphene citrate (CC) is prescribed off-label in men to improve testosterone and sperm parameters, but the duration of treatment needed to reach maximal benefit remains unclear. Our objective was to examine temporal effects of CC on total testosterone (TT) and semen analysis (SA) using longitudinal follow-up data in treated men.
Materials And Methods: We analyzed an IRB-approved database of men treated with CC (25 mg q.
Purpose: The safety label for collagenase was updated to include postinjection acute lower back pain as an adverse event observed with intralesional therapy for Peyronie's disease. Incidence and causality are unknown. We assessed frequencies and temporal associations for this adverse event in a large cohort.
View Article and Find Full Text PDFBackground: Efficacy of clomiphene citrate (CC) in the treatment of male subfertility remains unclear, with inconsistent results in the literature and limited guidance from professional organizations. We sought to stratify the response to clomiphene in men based on their initial gonadotropins and semen parameters.
Methods: We conducted a retrospective analysis of 234 patients from an academic center who took CC for subfertility.