Increased platelet counts are associated with female sex and asthma severity.

Background: Significant sex differences occur in asthma phenotypes across the lifespan. Platelet activation is associated with a steroid-refractory asthma phenotype.

Objective: We sought to test the hypothesis that higher platelet counts in females are associated with increased prevalence and severity of asthma compared with males.

The role of ACT score in mepolizumab discontinuation.

Background: Mepolizumab is a therapy for severe asthma. We have little knowledge of the characteristics of people in the US that discontinue mepolizumab in clinical care.

Objective: To investigate the real-world efficacy and time to clinical discontinuation of mepolizumab, we evaluated individuals with asthma started on mepolizumab at the Cleveland Clinic.

Nitrogen dioxide, an EPA parameter, may forecast the incidence of asthma exacerbations across urban areas: An observational study.

Rationale: Efforts to reduce nitrogen dioxide (NO ) have the potential to reduce the morbidity and mortality related to asthma in children. We analyze the associations of pediatric hospital admission rates for asthma with Environmental Protection Agency (EPA) NO  parameters at the patient zip code level.

Methods: We identified zip codes that had EPA monitors which monitored NO  levels located in states with high asthma burden.