Publications by authors named "Negar Etebar"
Ras-related C3 botulinum toxin substrate 1 (Rac1) is a small GTPase belonging to the Rho family. It acts as a binary molecular switch regulating several cellular functions, including cell adhesion and migration. Malfunctions due to the P29S mutation in Rac1 increase the stability of the activated form of Rac1.
View Article and Find Full Text PDFMultiple sclerosis (MS) is a chronic neurodegenerative, inflammatory, and demyelinating disease of the central nervous system (CNS). Current medicines are not sufficient to control the inflammation and progressive damage to the CNS that is known in MS. These drawbacks highlight the need for novel treatment options.
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- Cellular ACE2 (cACE2) is crucial for maintaining a balance between harmful AngII and protective Ang (1-7) in the brain's renin-angiotensin system, essential for normal brain function.
- SARS-CoV-2 uses cACE2 to enter cells, leading to its downregulation, which disrupts the balance of brain-RAS and undermines neuroprotective pathways, resulting in inflammation and oxidative stress.
- This disruption is linked to various neurological issues in COVID-19 patients, including sensory disturbances and cerebrovascular problems, highlighting the importance of RAS in brain health during viral infections.