Publications by authors named "Nathan Van Bibber"
Human Immunodeficiency Virus-Associated Differences in the Tumor Immune Microenvironment of Lung, Breast, and Prostate Cancers.
Cancer Epidemiol Biomarkers Prev
June 2025
Background: Cancer outcomes in people living with human immunodeficiency virus (PWH) may be driven in part by a distinct tumor microenvironment (TME) for cancers that develop in the setting of persistent immune dysfunction.
Methods: Tumor samples from PWH were retrospectively obtained from the AIDS Cancer Specimen Resource, Moffitt Cancer Center, and Huntsman Cancer Institute. Staining of 22 different tumor immune markers was compared between PWH and cancer and patients diagnosed with the same cancer type but without human immunodeficiency virus.
Background: People living with HIV (PWH) have improved life expectancy because of effective human immunodeficiency virus (HIV) therapy but still experience immune impairment (e.g., altered CD4/CD8 T cells).
View Article and Find Full Text PDFEpstein-Barr virus (EBV) is associated with a diverse range of lymphomas. EBV-specific T-cell (EBVST) infusions have shown promise in safety and clinical effectiveness in treating EBV-associated lymphomas; however, not all patients respond to T-cell immunotherapies. To identify EBV antigen-specific antibody responses associated with clinical outcomes, we comprehensively characterized antibody responses to the complete EBV proteome using a custom protein microarray in 56 patients with EBV-associated lymphoma who received EBVST infusions in phase 1 clinical trials.
View Article and Find Full Text PDFArticle Synopsis
- Epstein-Barr virus (EBV) is linked to various types of lymphomas, and while EBV-specific T-cell (EBVST) therapies have shown effectiveness, not all patients benefit from them.
- A study analyzing immune responses in 56 lymphoma patients receiving EBVST treatments discovered distinct antibody profiles that differentiate responders from non-responders, particularly at 3 months after treatment.
- The research identified 10 specific IgG antibodies that can predict clinical responses, suggesting that these EBV-directed antibodies may serve as biomarkers for patient outcomes in EBV-associated lymphoma treatments.
Article Synopsis
- The COVID-19 pandemic disrupted cancer care, particularly affecting immunosuppressed patients, leading to delays in treatment initiation for people living with HIV (PLWH) compared to the general cancer population (GCP) and those with a history of solid organ transplants (SOT).
- A study analyzed data from US patients with various cancer types between 2018 and 2021, finding that PLWH faced significant delays—about one month longer—when starting cancer treatment during the first year of the pandemic.
- The delays were noted across different treatment types, indicating a potential negative impact on cancer outcomes for PLWH, highlighting the need for increased attention from both patients and providers as the healthcare system continues to deal
Intrinsic Disorder in Human Proteins Encoded by Core Duplicon Gene Families.
J Phys Chem B
September 2020
Article Synopsis
- * Core duplicon gene (CDG) families consist of these duplications and are interesting because they contain shared "core" DNA while potentially adding new protein functions and exhibiting multifunctionality in their encoded proteins.
- * A study of 10 CDG families revealed that many of their proteins are highly disordered, meaning they lack a fixed structure, which may facilitate protein interactions and various modifications after translation.
Article Synopsis
- - Tetratricopeptide repeats (TPRs) are protein motifs made up of 34 amino acids, commonly found in proteins that facilitate interactions between other proteins, typically organized in stacks of 2 to 20 repeats.
- - Many repeat-containing proteins, including TPRs, exhibit high levels of intrinsic disorder, meaning they lack a fixed structure and can be flexible in their functions and interactions.
- - A study of 166 human TPR proteins showed varying degrees of intrinsic disorder, highlighting the presence of disordered regions that play essential roles in protein interactions and can be modified through posttranslational modifications.