Methotrexate improves left ventricle systolic and diastolic function in induced Takotsubo myocardiopathy rats.

Takotsubo syndrome (TTS) is a stress-induced cardiomyopathy which is associated with important morbidity and in-hospital mortality. Microvascular dysfunction, inflammation and fibrosis may play crucial roles in TTS pathophysiology. Here we investigated the effect of methotrexate (MTX), an antiproliferative and immunosuppressive drug, on ventricular function in a rat model of Takotsubo syndrome.

Treatment With Methotrexate Associated With Lipid Core Nanoparticles Prevents Aortic Dilation in a Murine Model of Marfan Syndrome.

In Marfan syndrome (MFS), dilation, dissection, and rupture of the aorta occur. Inflammation can be involved in the pathogenicity of aortic defects and can thus be a therapeutic target for MFS. Previously, we showed that the formulation of methotrexate (MTX) associated with lipid nanoparticles (LDE) has potent anti-inflammatory effects without toxicity.