Publications by authors named "Nadia MacSween"
Background: There is growing evidence linking neonatal vitamin D deficiency to an increased risk of schizophrenia, ADHD, and autism spectrum disorder (ASD). The aim of this study was to examine the association between two vitamin D biomarkers (25 hydroxyvitamin D [25(OH)D] and vitamin D-binding protein [DBP], and their related genetic correlates) and the risk of six mental disorders.
Methods: We used a population-based, case-cohort sample of all individuals born in Denmark between 1981 and 2005.
Article Synopsis
- The prevalence of autism in Denmark is rising, affecting 1.65% of 10-year-olds, with a focus on understanding its molecular causes through neonatal metabolomics of dried blood spots.
- Researchers analyzed metabolomic profiles from over 1,400 newborns later diagnosed with autism, identifying over 800 metabolite features using advanced mass spectrometry techniques.
- Key findings include two metabolites, cyclo-leucine-proline and 5-aminovaleric acid betaine (5-AVAB), which are associated with increased autism risk and could serve as early biomarkers, with 5-AVAB also linked to dietary habits and certain genetic variants.
Effects of Long-Term Storage on the Biobanked Neonatal Dried Blood Spot Metabolome.
J Am Soc Mass Spectrom
April 2023
Over 2.5 million neonatal dried blood spots (DBS) are stored at the Danish National Biobank. These samples offer extraordinary possibilities for metabolomics research, including prediction of disease and understanding of underlying molecular mechanisms of disease development.
View Article and Find Full Text PDFNeonatal dried blood spots (DBS) provide a remarkable resource for biobanks. These microsamples can provide information related to the genetic correlates of disease and can be used to quantify a range of analytes, such as proteins and small molecules. However, after routine neonatal screening, the amount of DBS sample available is limited.
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