Synthesis, Characterization, Biological Evaluation, DFT Calculations, and Molecular Docking Study of Transition Metal Complexes Derived From a Schiff Base Ligand.

The escalating global challenge of antibiotic resistance amid rising oxidative stress emphasizes the critical necessity for innovative antimicrobial strategies. This study, reported synthesis of Schiff base ligand, (Z)-2-[(4-nitrobenzylidene)amino]phenol (HL), derived from condensation between 2-aminophenol and 4-nitrobenzaldehyde, and it Co(II), Ni(II), Cu(II), and Zn(II) complexes. The compounds were characterized using NMR, FTIR, UV-Vis, MS, TGA, SEM-EDX, and elemental (CHN) analysis.