KilR of Rac prophage is a dual inhibitor of bacterial cell division and elongation machineries.

Bacterial cryptic prophages not only encode genes that reduce the viability of the host upon induction but also contribute to host survival during stressful conditions. Rac is a cryptic prophage of , and it encodes a toxic protein KilR, which causes morphological defects to the host. However, the mechanistic basis of its action is not well understood.

Proteomic profiling spotlights the molecular targets and the impact of the natural antivirulent umbelliferone on stress response, virulence factors, and the quorum sensing network of .

easily adapts to newer environments and acquires several genome flexibilities to overcome the effect of antibiotics during therapeutics, especially in cystic fibrosis patients. During adaptation to the host system, the bacteria employ various tactics including virulence factor production and biofilm formation to escape from the host immune system and resist antibiotics. Hence, identifying alternative strategies to combat recalcitrant pathogens is imperative for the successful elimination of drug-resistant microbes.