Publications by authors named "Muhammad Sheharyar Ashraf"
Objective: This study aimed to evaluate intensive care doctors' views about a large-scale pragmatic minimum mean arterial pressure (MAP) targets trial and their attitudes and beliefs about minimum MAP targets in different clinical scenarios.
Design: An online survey was conducted.
Setting And Participants: An online survey was distributed to intensive care doctors in sites participating in a large-scale international randomised clinical trial evaluating oxygen therapy targets in 15 countries and to additional intensive care clinicians from Canada.
Article Synopsis
- - The
- Mega-ROX HIE trial
- is an international study designed to compare conservative versus liberal oxygen therapy in adults with hypoxic ischaemic encephalopathy (HIE) after cardiac arrest who are on mechanical ventilation in ICU settings.
- - The
- trial aims to enroll around 4,000 participants
- and will measure all-cause mortality within 90 days from randomization as its primary outcome, alongside several secondary outcomes related to survival and hospital stay.
- - The study is structured to reduce any potential analysis bias by clearly outlining its
- protocol and statistical analysis plan
- , and aims to provide insights into effective oxygen therapies for this population.
Background: The effect of conservative vs. liberal oxygen therapy on 90-day in-hospital mortality in adults who have nonhypoxic ischaemic encephalopathy acute brain injuries and conditions and are receiving invasive mechanical ventilation in the intensive care unit (ICU) is uncertain.
Objective: The objective of this study was to summarise the protocol and statistical analysis plan for the Mega-ROX Brains trial.
Background: The effect of conservative vs. liberal oxygen therapy on 90-day in-hospital mortality in adults with sepsis receiving unplanned invasive mechanical ventilation in the intensive care unit (ICU) is uncertain.
Objective: The objective of this study was to summarise the protocol and statistical analysis plan for the Mega-ROX Sepsis trial.