Racial and ethnic minority groups, female sex, and tissue loss are associated with increased risk for hospital readmission following revascularization for chronic limb-threatening ischemia.

Background: Unplanned hospital readmission following surgery for peripheral arterial disease is among the highest in all diagnosis-related groups. Although previous studies have examined readmissions in certain subgroups, such as for patients undergoing lower extremity bypass, few have examined longer term readmissions for those with the most severe form of peripheral arterial disease, chronic limb-threatening ischemia (CLTI). Among patients with CLTI undergoing revascularization, we sought to outline rates of readmission beyond 30 days up to 1 year and identify patient and procedural characteristics associated with readmission.

GSDMD Deficiency Attenuates the Development of Ascending Aortic Dissections in a Novel Mouse Model.

Background: Mechanisms driving the development of type A aortic dissection (TAD) are currently poorly understood, and animal models of spontaneous TAD are limited. In the present study, we developed a novel mouse TAD model and evaluated the role of GSDMD (gasdermin D) in TAD development.

Methods: TADs were created by treating the ascending aorta of adult C57BL/6J mice with Act E (active elastase) and β-aminopropionitrile.

Gasdermin D deficiency attenuates development of ascending aortic dissections in a novel mouse model.

Background: Thoracic aortic dissection (TAD) is a silent killer. Approximately two-thirds of the cases occur in the ascending aorta (i.e.

Defect width and operative time are the most significant predictors of venous thromboembolism in ventral hernia repair.

Background: Venous thromboembolism is a significant cause of morbidity and mortality among patients undergoing ventral hernia repair. Several risk-assessment models have been developed to predict venous thromboembolism risk for various surgical procedures. However, these models do not include hernia-specific risk factors.