Publications by authors named "Muhammad Azhar Chishti"
Background And Objectives: Chromosomal abnormalities play an important role in genesis of acute lymphoblastic leukemia (ALL) and have prognostic implications. Five major risk stratifying fusion genes in ALL are BCR-ABL, MLL-AF4, ETV6-RUNX11, E2A-PBX1 and SIL-TAL1. This work aimed to detect common chromosomal translocations and associated fusion oncogenes in adult ALL patients and study their relationship with clinical features and treatment outcome.
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- Chemerin is a chemoattractant linked to the differentiation and metabolism of fat cells, and its expression varies by gender and fat tissue type, which was explored in this study.
- The research involved measuring body mass index (BMI) and chemerin levels along with other markers related to inflammation and insulin resistance in obese adults, revealing that chemerin levels are positively correlated with BMI and leptin but not with insulin resistance indicators.
- Differences in chemerin mRNA expression were found, being higher in women and in subcutaneous compared to visceral fat, suggesting that fat tissue type plays a crucial role in obesity-related metabolic functions.
Hsp-72, a candidate prognostic indicator of heatstroke.
Cell Stress Chaperones
September 2010
Exposure of rats to environmental heat enhances the expression of heat shock protein-72 (Hsp-72) in most of their organs proportionally to heat stress severity. Pre-induction or over-expression of Hsp-72 prevents organ damage and lethality, suggesting that heat shock proteins (Hsps) may have a pathogenic role in this condition. We investigated the expression profile of Hsps in baboons subjected to environmental heat stress until the core temperature attained 42.
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