Publications by authors named "Morimasa Takayama"
Scoring of cardiac damage evaluated by echocardiography predicts prognosis of patients with severe aortic stenosis undergoing transcatheter aortic valve implantation: analysis of the LAPLACE-TAVI registry.
Heart Vessels
July 2025
Transcatheter aortic valve implantation (TAVI) has become available for elderly patients with aortic stenosis (AS). However, no markers have been established to predict prognosis after TAVI. Cardiac damage caused by AS progresses sequentially in most cases through the left ventricle, left atrium, and right ventricle.
View Article and Find Full Text PDFAim: A rapid and effective risk stratification method is highly important for the emergency care of patients with acute heart failure with preserved ejection fraction (HFpEF). Previous studies, including our own, have suggested that heart rate, age, and systolic blood pressure contribute to the pathophysiology of HFpEF. This study aimed to examine the predictive utility of the thrombolysis in myocardial infarction risk index (TRI)-consisting of heart rate, age, and systolic blood pressure-for determining the in-hospital mortality in patients with acute HFpEF.
View Article and Find Full Text PDFCircadian variation in patients with acute heart failure with preserved ejection fraction.
Minerva Cardiol Angiol
April 2025
Background: The circadian system influences the pathophysiology of many cardiovascular diseases; however, circadian variations in patients with heart failure with preserved ejection fraction (HFpEF) are unknown. Thus, this study aimed to compare the clinical characteristics and risk factors for in-hospital mortality between patients with daytime- versus nighttime-onset HFpEF.
Methods: This multicenter retrospective study included 3875 consecutive patients with acute HFpEF.
Background: The Japanese Hypertrophic Cardiomyopathy Registry Study was designed to provide comprehensive, real-world insights into the clinical characteristics and management of hypertrophic cardiomyopathy (HCM) in Japan.
Methods: This multicentre, prospective study enrolled consecutive patients with HCM from 24 referral hospitals across Japan starting in 2016. The baseline characteristics of 1485 patients enrolled by December 2019 are presented in this analysis.
Specific phenotypes of heart failure with preserved/reduced ejection fraction according to Body Mass Index.
Minerva Cardiol Angiol
August 2025
Background: The relationship between Body Mass Index (BMI) and acute heart failure (HF) remains ill-defined. This study aimed to compare the influence of BMI on in-hospital mortality between patients with acute HF with preserved ejection fraction (HFpEF) and those with acute HF with reduced ejection fraction (HFrEF) and to examine the specific phenotypes of HFpEF/HFrEF according to BMI.
Methods: This multicenter retrospective study included 5313 and 6332 consecutive patients with acute HFpEF and HFrEF, respectively.
We appreciate the comments from Arshad et al. regarding our study on long-term outcomes of alcohol septal ablation (ASA) for hypertrophic obstructive cardiomyopathy (HOCM) in Japan. Addressing concerns about sex-related differences, our analyses revealed no significant differences between men and women in overall mortality (log-rank P = 0.
View Article and Find Full Text PDFHospital Variability in the Use of Vasoactive Agents in Patients Hospitalized for Acute Decompensated Heart Failure for Clinical Phenotypes.
Circ Cardiovasc Qual Outcomes
March 2025
Background: The absence of practice standards in vasoactive agent usage for acute decompensated heart failure has resulted in significant treatment variability across hospitals, potentially affecting patient outcomes. This study aimed to assess temporal trends and institutional differences in vasodilator and inotrope/vasopressor utilization among patients with acute decompensated heart failure, considering their clinical phenotypes.
Methods: Data were extracted from a government-funded multicenter registry covering the Tokyo metropolitan area, comprising consecutive patients hospitalized in intensive/cardiovascular care units with a primary diagnosis of acute decompensated heart failure between January 2013 and December 2021.
Optimal ablation pattern on intraprocedural echocardiography is associated with favorable clinical outcomes of alcohol septal ablation for hypertrophic obstructive cardiomyopathy.
J Cardiol
July 2025
Background: Alcohol septal ablation (ASA) is used to treat drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). Intraprocedural echocardiography is essential for identifying the septal area perfused by each septal branch; however, its role in determining the procedural endpoint of ASA remains unclear. This retrospective study aimed to evaluate the impact of intraprocedural echocardiographic findings on clinical outcomes and left ventricular pressure gradient (LVPG) after ASA.
View Article and Find Full Text PDFArticle Synopsis
- Diabetes is a significant risk factor for cardiovascular diseases but exhibits a "diabetes paradox" in Takotsubo syndrome, where it may not negatively affect outcomes, although this remains debated.
- In a study analyzing 1,226 Takotsubo syndrome patients, the prevalence of diabetes was found to be similar to that of the general population (17.0% vs. 15.8%).
- The study concluded that diabetes does not have a protective effect in Takotsubo syndrome and may even be linked to higher in-hospital mortality rates, challenging the belief that diabetes could be beneficial in this context.
Hypertrophic cardiomyopathy is characterized by significant left ventricular wall thickening, often leading to obstructive symptoms. Alcohol septal ablation (ASA) has emerged as an effective treatment for patients with hypertrophic obstructive cardiomyopathy (HOCM) who remain symptomatic despite maximal medical therapy. However, the detailed long-term effects of ASA in Japanese patients with HOCM remain unclear.
View Article and Find Full Text PDFArticle Synopsis
- Mavacamten, a cardiac myosin inhibitor, showed significant improvements in symptoms and heart function in Japanese patients with obstructive hypertrophic cardiomyopathy (HCM) during the HORIZON-HCM study.
- In a trial involving 38 patients, 36 completed the 30-week treatment, which resulted in a notable reduction in postexercise left ventricular outflow tract (LVOT) gradient and improvements in cardiac biomarkers and quality of life metrics.
- The treatment was well tolerated, with adverse events reported but none leading to discontinuation, and no deaths occurred throughout the study.
Impact of prior hospitalization for heart failure on clinical outcomes of patients after transcatheter aortic valve implantation with new-generation devices: Insights from the LAPLACE-TAVI registry.
Catheter Cardiovasc Interv
December 2024
Article Synopsis
- A history of hospitalization for heart failure (HHF) before transcatheter aortic valve implantation (TAVI) is linked to poorer clinical outcomes in patients with severe aortic stenosis (AS).
- In a study of 2,752 patients, those with prior HHF had significantly higher 30-day mortality and overall risk of negative outcomes compared to those without such a history.
- The findings highlight that prior HHF affects patients regardless of their heart function, emphasizing the need for careful evaluation and management in these cases post-TAVI.
Article Synopsis
- Researchers analyzed the characteristics and outcomes of 22,236 patients with myocardial infarction, focusing on the 286 diagnosed with non-obstructive coronary arteries (MINOCA) from the Japan Acute Myocardial Infarction Registry.
- MINOCA patients were generally younger and had fewer risk factors compared to those with obstructive coronary artery disease (MI-CAD), but in-hospital mortality rates were similar between the two groups.
- The study found higher non-cardiac mortality in MINOCA patients, especially among the elderly, indicating a need for better overall management and care for younger patients to improve their health outcomes.
Article Synopsis
- The study examined the effects of the vasopressin V receptor antagonist tolvaptan on mortality in congestive heart failure (CHF) patients with hypoperfusion.
- Data from 5511 CHF patients showed that those with the wet-cold pattern (hypoperfusion) had significantly higher in-hospital mortality compared to those without.
- Tolvaptan was linked to reduced in-hospital mortality specifically in the CHF patients with hypoperfusion, suggesting potential tailored treatments for different CHF patient profiles.
Article Synopsis
- * Recent findings emphasize that the mitral valve, papillary muscle issues, and an apical-basal muscle bundle also contribute significantly to this obstruction, not just the typical septal hypertrophy.
- * Four-dimensional computed tomography is recommended for detailed assessment and planning of surgical intervention in HCM, offering better imaging capabilities than traditional methods like echocardiography or cardiac MRI.
Article Synopsis
- - The study analyzed data from 3,089 patients with DeBakey type I/II acute aortic dissection to assess the differences in clinical presentation and outcomes based on sex during treatment.
- - Findings indicated that women generally presented with more severe conditions (e.g., hyperlipidemia, altered consciousness) and had higher rates of specific complications, while men had higher surgical mortality and preoperative complications.
- - In surgical patients, male sex was linked to a significantly higher in-hospital mortality rate, but no similar association was observed in medically treated patients, highlighting the need for further investigation into these outcomes.
Background: The comparative efficacy and safety of adjusted- and standard-dose prasugrel in East Asian patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) remain unclear. This study aimed to comparatively assess the ischaemic and bleeding outcomes of adjusted-dose (maintenance dose: 3.75 mg) and standard-dose (maintenance dose: 10 mg) prasugrel in East Asian patients with AMI undergoing PCI.
View Article and Find Full Text PDFComparison of clinical characteristics and prognostic factors in patients with heart failure with preserved ejection fraction with and without renal dysfunction.
Minerva Cardiol Angiol
December 2024
Article Synopsis
- The study focused on comparing in-hospital mortality rates between heart failure with preserved ejection fraction (HFpEF) patients who have renal dysfunction (RD) and those who do not.
- It included 5867 patients, revealing that 68% had RD and that those patients had significantly higher in-hospital mortality.
- Key prognostic factors for mortality varied between the two groups, with notable differences in age, blood pressure, eGFR, C-reactive protein levels, and the use of certain medications.
Article Synopsis
- The study investigates heart failure incidence and outcomes in patients who survived an acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention.
- Out of 3,411 AMI patients, 124 (3.8%) were admitted for heart failure, with significant factors including age, sex, and heart function at admission.
- The heart failure group experienced significantly higher rates of all-cause mortality and major cardiovascular events compared to those without heart failure admissions (11.3% vs. 2.5% for mortality).
Background: Epidemiological data on ruptured aortic aneurysms from large-scale studies are scarce. The aims of this study were to: clarify the clinical course of ruptured aortic aneurysms; identify aneurysm site-specific therapies and outcomes; and determine the clinical course of patients receiving conservative therapy.
Methods And Results: Using the Tokyo Acute Aortic Super Network database, we retrospectively analyzed 544 patients (mean [±SD] age 78±10 years; 70% male) with ruptured non-dissecting aortic aneurysms (AAs) after excluding those with impending rupture.
Article Synopsis
- Bleeding complications are a significant concern for acute heart failure patients using mechanical circulatory support like the Impella device, with the J-PVAD registry aimed at analyzing these risks among Japanese patients.
- The study included 1344 patients from October 2017 to January 2020, revealing a 30-day survival rate of 67% overall, with those using Impella alone showing higher survival at 81.9%.
- Bleeding events were recorded at 6.92%, with specific rates for hematoma and bleeding from access sites at 1.41% and 4.09%, respectively, indicating that the findings align with previous reports on bleeding complications in similar patient populations.
Prevalence and clinical characteristics of diabetic cardiomyopathy in patients with acute heart failure.
Nutr Metab Cardiovasc Dis
May 2024
Article Synopsis
- Diabetic cardiomyopathy is a condition where diabetes complicates heart function, occurring without high blood pressure or existing heart disease, but its prevalence is unclear due to the overlap of diabetes and hypertension.
- A study involving over 17,000 patients with acute heart failure found that diabetic cardiomyopathy was present in 1.6% of the total group, with higher rates (5.2% and 10%) in patients with diabetes-related heart issues.
- Patients with diabetic cardiomyopathy faced a much higher in-hospital mortality rate (7.7%) compared to those with diabetes-related heart failure who also had hypertension (2.8%), indicating a need for awareness and different management for these patients.