Publications by authors named "Morgan A Howells"
Article Synopsis
- Mammalian orthoreovirus spreads throughout the body via the blood, and its hematogenous dissemination is influenced by the nonstructural protein σ1s, which helps the virus replicate efficiently in various cells.
- The study reveals that lymphatic type 1 interferon (IFN-1) responses play a significant role in restricting reovirus spread, as a σ1s-deficient variant of the virus showed reduced systemic dissemination in the presence of intact IFN-1 signaling.
- The findings suggest that lymphatics are crucial for the virus's spread, with the σ1s protein enhancing resistance to the antiviral effects of IFN-1, thereby facilitating the reovirus's ability to infect other organs.
Reovirus is under development as a therapeutic for numerous types of cancer. In contrast to other oncolytic viruses, the safety and efficacy of reovirus have not been improved through genetic manipulation. Here, we tested the oncolytic capacity of recombinant strains (rs) of prototype reovirus laboratory strains T1L and T3D (rsT1L and rsT3D, respectively) in a panel of non-small cell lung cancer (NSCLC) cell lines.
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