Pregnancy outcomes in C3 glomerulopathy: a retrospective review.

Background: C3 Glomerulopathy (C3G) is an ultra-rare glomerular disease driven by dysregulation of the alternative pathway of complement. 30-50% of adult patients progress to end stage kidney disease (ESKD) within 10 years of diagnosis. Little is known of the impact of pregnancy on the natural history of C3G or whether a coincident diagnosis of C3G affects maternal-fetal outcomes.