Core Outcome Sets for Meningioma In Clinical studies (COSMIC): An international patient and healthcare professional consensus for research studies.

Background: Core Outcome Sets (COS) define the minimum outcomes that should be measured and reported in all clinical trials for a specific health condition or health area. The aim was to develop 2 COS for intracranial meningioma to be used in future clinical studies: COSMIC: Intervention for effectiveness trials and COSMIC: Observation for studies of incidental/untreated meningioma.

Methods: A study advisory group was formed with representation from international stakeholder groups: EORTC BTG, ICOM, EANO, SNO, RANO-PRO, BNOS, SBNS, BIMS, TBTC, International Brain Tumour Alliance, and Brainstrust.

Preliminary Experience with the use of a 3-Dimensional Exoscope for Excision of Unruptured Brain Arteriovenous Malformations: Case Series and Comparative Analysis.

Objective: To assess the use of a 3-dimensional exoscope in the resection of unruptured brain arteriovenous malformations (AVMs).

Methods: Unruptured brain AVMs resected by a single surgeon using 3-dimensional exoscope ORBEYE (Olympus-Tokyo-Japan) were compared with AVMs (matched for size and Spetzler-Martin [SM] grade) resected using the operating microscope (OM), prospectively collected over more than 2 years.

Results: 14 patients (7 females) with AVMs resected using the exoscope formed a case series and were compared with 21 patients (7 females) operated using the OM.

Intra-operative neurophysiological monitoring as an adjunct to resection of eloquent cerebral arteriovenous malformations: a retrospective cohort study.

Background: Arteriovenous malformations (AVM) carry a risk of haemorrhage and may also cause epilepsy or ischaemic steal phenomenon. Surgical resection leads to high rates of lesion obliteration but resection of AVMs located in eloquent cortex is associated with high rates of morbidity. The aim of this study was to assess the outcomes following surgical resection of AVMs in eloquent cortical locations with the use of intra-operative neuro-monitoring (IoNM).

Monitoring of microsurgically and endovascularly treated aneurysms (META): protocol for an international multicentre retrospective cohort study.

Introduction: Following endovascular treatment (EVT) or microsurgical treatment (MT) of intracranial aneurysms (IA), radiological follow-up is performed to assess for recurrence and to determine the need for re-treatment. There is a paucity of evidence describing the long-term results of EVT and MT for IA and therefore data to inform the design of follow-up protocols are lacking. The overarching aim of the META study is to determine the clinically relevant long-term outcomes of EVT and MT for IA, and use this data to create evidence based radiological and clinical follow-up protocols for these aneurysms.

Outcomes following stereotactic radiosurgery for high-grade brain arteriovenous malformations: a systematic review and meta-analysis.

Objective: Arteriovenous malformations (AVMs) of the brain are a leading cause of stroke in the young and carry a lifetime risk of intracerebral hemorrhage. The management options for high-grade AVMs are limited. Resection is often associated with high rates of postoperative morbidity, and the results of stereotactic radiosurgery (SRS) for these lesions thus far have been mixed.

Re-evaluating patient communication and care in angiographically negative subarachnoid hemorrhage: Balancing realism and optimism.

Angiographically negative subarachnoid hemorrhage (anSAH) has traditionally been considered a benign condition, mainly because of favorable outcomes in the acute stage in comparison to the often negative acute outcomes of aneurysmal subarachnoid hemorrhage. However, a growing body of research in recent years shows that anSAH often leads to cognitive impairments, emotional distress, and difficulties in resuming work or other daily life activities. Therefore, in this position paper, we call for a change in neurological care and a shift in patient communication, emphasizing the importance of addressing patient needs and fostering realistic expectations rather than solely focusing on the benign nature of the condition.

Evaluation of severe traumatic brain injury referrals to the National Tertiary Neurosurgical Centre in the Republic of Ireland.

Background: Transfer of all severe TBI patients to a neurosurgical unit (NSU) has been advocated irrespective of levels of complexity and prognostic factors. Previous publications have suggested that only 50% of severe TBI patients in Ireland were managed in NSUs.

Aims: This study aims to audit severe TBI referrals to the National Neurosurgical Centre, to evaluate reasons for nonacceptance, assess for differences in the transferred and not transferred cohorts and to analyse observed and expected mortality rates.

Outcomes following poor-grade aneurysmal subarachnoid haemorrhage: a prospective observational study.

Background: Up to 35% of aneurysmal subarachnoid haemorrhage (aSAH) cases may present as poor grade, defined as World Federation of Neurosurgical Societies (WFNS) grades IV and V. In this study, we evaluate functional outcomes and prognostic factors.

Methods: This prospective study included all patients referred to a national, centralized neurosurgical service with a diagnosis of poor-grade aSAH between 01/01/2016 and 31/12/2019.

Risk factor synergism in aneurysmal subarachnoid hemorrhage: a cross-sectional study.

Background: Spontaneous subarachnoid hemorrhage (SAH) accounts for 5-10% of strokes but a disproportionately large amount of stroke-related morbidity. Several risk factors have been described, including smoking, hypertension, increasing age, and female sex.

Methods: This cross-sectional study examined all patients with aSAH within a nationally representative catchment from 01/01/2017 to 31/12/2020.

Multidisciplinary Management of Lateral Skull Base Paragangliomas: A 20-Year Experience.

 Paragangliomas of the lateral skull base are rare, largely benign, neuroendocrine tumors. Little evidence exists to support clinicians in the management of these tumors. The present study evaluates considerations in the multidisciplinary workup and management of paragangliomas affecting the lateral skull base.

Meningioma in the elderly.

Meningiomas are the most common primary intracranial neoplasm, accounting for approximately 40% of all primary brain tumors. The incidence of meningioma increases with age to 50 per 100,000 in patients older than 85. As the population ages, an increasing proportion of meningioma patients are elderly.

Aneurysm management in patients over 80 years old with good grade subarachnoid haemorrhage.

Background: An increasing proportion of aneurysmal subarachnoid haemorrhage (aSAH) occurs in older patients, in whom there is widespread variability in treatment rates due to a different balance of risks. Our aim was to compare outcomes of patients over 80 years old with good grade aSAH who underwent treatment of their aneurysm with those who did not.

Methods: Adult patients with good grade aSAH admitted to tertiary regional neurosciences centres contributing to the UK and Ireland Subarachnoid Haemorrhage Database (UKISAH) and a cohort of consecutive patients admitted from three regional cohorts were included for analysis.

Multi-layered repair of high-flow CSF fistulae following endoscopic skull base surgery without nasal packing or lumbar drains: technical refinements to optimise outcome.

Aims: Post-operative CSF leak remains a significant problem following endoscopic skull base surgery, particularly when there is a high-flow intra-operative CSF leak. Most skull base repair techniques are accompanied by the insertion of a lumbar drain and/or the use of nasal packing which have significant shortcomings. Our aim was to review the results of a large series of endoscopic skull base cases where a high-flow intra-operative CSF leak rate was encountered and repaired to assess if modifications in technique could reduce the post-operative CSF leak rate.

The weekend effect in aneurysmal subarachnoid haemorrhage: a single centre experience and review.

Clinical outcomes for patients admitted to hospital during weekend hours have been reported to be poorer than for those admitted during the week. Aneurysmal subarachnoid haemorrhage (aSAH) is a devastating form of haemorrhagic stroke, with a mortality rate greater than 30%. A number of studies have reported higher mortality for patients with aSAH who are admitted during weekend hours.

WITHDRAWN: Middle Meningeal Artery Embolization for Chronic Subdural Hematoma-A New Treatment Paradigm?

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.

Predictive factors for pre-intervention rebleeding in aneurysmal subarachnoid haemorrhage: a systematic review and meta-analysis.

Rebleeding before intervention is a devastating complication of aneurysmal subarachnoid haemorrhage (aSAH). It often occurs early and is associated with poor outcomes. We present a systematic review and meta-analysis to identify potential predictors of rebleeding in aSAH.

Management of Chronic Subdural Hematoma: A Systematic Review and Component Network Meta-analysis of 455 Studies With 103 645 Cases.

Background: Chronic subdural hematoma (CSDH) is a common neurosurgical condition with a high risk of recurrence after treatment.

Objective: To assess and compare the risk of recurrence, morbidity, and mortality across various treatments for CSDH.

Methods: A systematic review and meta-analysis was performed.